CRC 1116 "Master switches in cardiac ischemia"

Summary

The fundamental and prospective aim of the CRC 1116 “Master switches in cardiac ischemia” is to identify new targets, i.e. molecules, pathways and mechanisms that are critical for the acute and subacute response to myocardial ischemia, which we define as “master switches”. Importantly, the CRC 1116 considers systemic cross talk of ischemic cardiac injury and systemic inflammatory responses, metabolic comorbidities (obesity, insulin resistance, type 2 diabetes (T2DM)) and anemia. The CRC 1116 is organized into two conceptual areas.

Project group A (intracellular and cellular effectors) will address key aspects of pathophysiologic responses to cardiac ischemia such as ion channel remodeling, sarcomere function in the remote myocardium, role of p27 and telomerase reverse transcriptase (TERT) in mitochondria, platelet functions beyond aggregation, growth factor signaling and modulators of G-protein coupled receptor signaling and their role for immune cell responses and cardiac myocyte responses, respectively, as well as in-depth analysis of the protective function of cardiac hyaluronan-rich matrix.

Project group B (metabolic and systemic effectors) focuses on the complex cross talk between infarct healing and cardiac adaptation and systemic effector systems and comorbidities. The projects in project group B address (i) mechanisms regulating the inflammatory response after cardiac ischemia such as the adenosine-interleukin-6 axis and co-stimulatory molecules to modulate T cell responses (ii) mechanisms underlying the confounding effects in patients with insulin resistance, obesity and T2DM, the so far unknown role of brown adipose tissue and of sphingosine 1 phosphate in myocardial ischemia and T2DM. Potential clinical translation is expected from investigating the confounding effects of T2DM on remote ischemic conditioning in a large animal model. Using translational approaches the impact of insulin resistance, non-alcoholic fatty liver disease with ectopic lipid deposition and of T2DM in ST elevation myocardial infarction (STEMI) will be studied in patients.

Thereby the CRC1116 will provide new targets (master switches) and/or treatment options taking into account the specific pathophysiological context determined by comorbidities and other systemic interferences. The identification of these “master switches” in the acute and subacute phase after cardiac ischemia will be useful to better stratify patients to targeted therapies and ultimately positively affect their long-term outcome. 

Latest News

News SFB 1116

10.12.18 11:27

PhD positions available starting in 2019

Applications are invited for PhD positions within the CRC 1116 “Master switches in cardiac ischemia”.  Please folllow this link for more Information: PhD Positions


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27.11.18 13:53

Collaborative Research Centre 1116 receives second grant for 4 years!

The German Research Foundation announced on November 26 that they will be funding the Collaborative Research Centre 1116 (CRC 1116) "Master Switches in cardiac ischemia" from the Heinrich Heine University for a


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22.11.18 11:03

Two new doctor titles: Dr. Senem Sahin and Dr. Malgorzata Isic

Senem Sahin and Malgorzata Isic both successfully completed their final PhD oral examination in November and were awarded their doctor titles.  Their PhD work was conducted in the laboratory of Professor Martina Krü


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03.09.18 15:32

Sidney & Joan Pestka Graduate & Post-Graduate Award goes to Erika Engelowski

The Collaborative Research Centre 1116 congratulates Erika Engelowski on receiving the Sidney & Joan Pestka Graduate Award.  Erika is a PhD student of Prof. Dr. Jürgen Scheller's at the Institute of Biochemistry


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13.07.18 09:54

Annette Kronenbitter has been awarded her PhD!

On the 13th July Annette Kronenbitter was awarded her PhD with a magna cum laude. The title of her thesis is "Altered sarcomere function and myocyte calcium cycling in the remote myocardium after myocardial infarction". 


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Spokesperson Collaborative Research Centre 1116

Prof. Dr. rer. nat. Jens W. Fischer

Institut für Pharmakologie und Klinische Pharmakologie Universitätsstr. 1 40225 Düsseldorf
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