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Project A01 (Klöcker)

Ventricular arrhythmogenesis by ion channel remodeling after acute myocardial infarction (AMI)

Ventricular arrhythmias are cause and prognostic marker of increased mortality early after AMI. Using an unbiased experimental approach (next generation sequencing) combined with optical mapping and mathematical modeling, loco-regional changes in expression and function of ionic conductances will be analyzed, which result in electrical instability of the injured myocardium. They will be target for exploring the therapeutic potential of innovative photopharmacological strategies for spatiotemporal modulation of ion channels.

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