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Junior Research Group (Bottermann)

Impact of peripheral white adipose tissue lipolysis on cardiac remodelling after myocardial infarction

During and after myocardial infarction, there is a compensatory increase in sympathetic tone and thus systemic beta-adrenergic stimulation. This is one of the strongest stimuli for lipolysis in peripheral white adipose tissue and leads to increased levels of circulating free fatty acids. We are investigating to what extent these circulating fatty acids and other adipose tissue derived factors have an influence on cardiac substrate metabolism and cardiac remodelling after myocardial infarction. Cardiac metabolism after myocardial infarction shows characteristic changes such as reduced glucose oxidation. Promotion of glucose oxidation seems to have a positive impact on cardiac remodelling after myocardial infarction. Our approach is to investigate whether peripheral adipose tissue lipolysis and lipolytic products may impact cardiac metabolism after myocardial infarction and to what extent it could therefore represent a possible therapeutic target in the treatment of myocardial infarction.

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