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Project B09 (Gerdes)

Co-stimulatory molecules as determinants of the acute immune response following cardiac ischemia reperfusion (IR) injury

Co-stimulatory molecules are central for shaping immune responses yet their function following myocardial infarction is not determined. Here, we will test the contribution of two co-stimulatory pathways, namely the CD40/CD40L and CD27/CD70 axes, to morphological and functional outcomes after myocardial infarction in mice. We will examine the cell type-dependent expression and function of these factors determining immune reaction after and recovery from cardiac ischemia/reperfusion injury in mice. By using genetic and pharmacological inhibition this project will help to understand the role of CD40/CD40L and CD27/CD70 following acute myocardial infarction.

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