Jump to contentJump to search

Project B10 (Grandoch/Flögel)

Unraveling the role of brown adipose tissue in myocardial ischemia/reperfusion injury

B10 aims to explore the so far unknown role of brown adipose tissue (BAT) in AMI using cutting-edge MR techniques. For this, BAT activation will be investigated pre- and post-I/R by a novel MRI T2 mapping approach as well as classical histological and molecular biology methods. In parallel, sub-strate metabolism will be longitudinally studied by non-invasive MR techniques for lipid profiling and glucose uptake in BAT and heart. BAT ablation will be utilized to elucidate its role for functional out¬come post I/R. Analyses will be expanded to diabetic conditions in a murine model and experimental data will be completed by first translational MR analyses of BAT activation in patients post AMI.


Doctoral Researcher

Arne Beran

Doctoral Researcher

Anne Vera Flocke
Responsible for the content: