Ventricular arrhythmogenesis by ion channel remodeling after acute myocardial infarction (AMI)
Project Group A: intracellular and cellular effectors
Project group A will therefore investigate new cardiac effector mechanisms. Specifically mechanisms of arrythmogenesis, cardiomyocyte dysfunction, regulation of mitochondrial function and apoptosis, new posttranslational mechanisms, cardioprotective signaling, effects of acute remodeling of cardiac extracellular matrix on angiogenesis and fibroblast phenotype and underlying molecular mechanisms will be investigated. Thus project group A addresses important adaptative and maladaptative processes that are initiated in the myocardium in the acute and subacute phase post AMI.