Publikationen

Aboouf MA, Armbruster J, Thiersch M, Gassmann M, Godecke A, Gnaiger E, Kristiansen G, Bicker A, Hankeln T, Zhu H, Gorr TA. Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159026.

Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, Unfried K, Brack F, Grandoch M, Thielmann M, Kamler M, Gedik N, Kleinbongard P, Heinen A, Heusch G, Godecke A, Altschmied J, Haendeler J. Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function. Circulation. 2021;144:1876-90.

Bertero E, Heusch G, Munzel T, Maack C. A pathophysiological compass to personalize antianginal drug treatment. Nat Rev Cardiol. 2021;18:838-52.

Bogorodskiy A, Okhrimenko I, Burkatovskii D, Jakobs P, Maslov I, Gordeliy V, Dencher NA, Gensch T, Voos W, Altschmied J, Haendeler J, Borshchevskiy V. Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases. Cells. 2021;10.

Bogorodskiy A, Okhrimenko I, Maslov I, Maliar N, Burkatovskii D, von Ameln F, Schulga A, Jakobs P, Altschmied J, Haendeler J, Katranidis A, Sorokin I, Mishin A, Gordeliy V, Buldt G, Voos W, Gensch T, Borshchevskiy V. Accessing Mitochondrial Protein Import in Living Cells by Protein Microinjection. Front Cell Dev Biol. 2021;9:698658.

Bottermann K, Granade ME, Oenarto V, Fischer JW, Harris TE. Atglistatin Pretreatment Preserves Remote Myocardium Function Following Myocardial Infarction. J Cardiovasc Pharmacol Ther. 2021;26:289-97.

Burnap SA, Sattler K, Pechlaner R, Duregotti E, Lu R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernandez-Hernando C, Berry SE, Hall WL, Notdurfter M, Rungger G, Paulweber B, Willeit J, Kiechl S, Levkau B, Mayr M. PCSK9 Activity Is Potentiated Through HDL Binding. Circ Res. 2021;129:1039-53.

Dannenberg L, Weske S, Kelm M, Levkau B, Polzin A. Cellular mechanisms and recommended drug-based therapeutic options in diabetic cardiomyopathy. Pharmacol Ther. 2021;228:107920.

Dichtl S, Lindenthal L, Zeitler L, Behnke K, Schlosser D, Strobl B, Scheller J, El Kasmi KC, Murray PJ. Lactate and IL6 define separable paths of inflammatory metabolic adaptation. Sci Adv. 2021;7.

Donner L, Feige T, Freiburg C, Toska LM, Reichert AS, Chatterjee M, Elvers M. Impact of Amyloid-beta on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. Int J Mol Sci. 2021;22.

Erkens R, Totzeck M, Brum A, Duse D, Botker HE, Rassaf T, Kelm M. Endothelium-dependent remote signaling in ischemia and reperfusion: Alterations in the cardiometabolic continuum. Free Radic Biol Med. 2021;165:265-81.

Flogel U, Temme S, Jacoby C, Oerther T, Keul P, Flocke V, Wang X, Bonner F, Nienhaus F, Peter K, Schrader J, Grandoch M, Kelm M, Levkau B. Multi-targeted (1)H/(19)F MRI unmasks specific danger patterns for emerging cardiovascular disorders. Nat Commun. 2021;12:5847.

Geist D, Hones GS, Gassen J, Kerp H, Kleinbongard P, Heusch G, Fuhrer D, Moeller LC. Noncanonical Thyroid Hormone Receptor alpha Action Mediates Arterial Vasodilation. Endocrinology. 2021;162.

Gil-Pulido J, Amezaga N, Jorgacevic I, Manthey HD, Rosch M, Brand T, Cidlinsky P, Schafer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. Interleukin-23 receptor expressing gammadelta T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. Cardiovasc Res. 2021;doi.org/10.1093/cvr/cvab359.

Hackert K, Homann S, Mir S, Beran A, Gorressen S, Funk F, Fischer JW, Grandoch M, Schmitt JP. 4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts. Hypertension. 2021;77:1918-27.

Hartmann F, Gorski DJ, Newman AAC, Homann S, Petz A, Owsiany KM, Serbulea V, Zhou YQ, Deaton RA, Bendeck M, Owens GK, Fischer JW. SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis. Circ Res. 2021;129:992-1005.

Heinen A, Godecke S, Flogel U, Miklos D, Bottermann K, Spychala A, Godecke A. 4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice. Basic Res Cardiol. 2021;116:8.

Heise D, Derrac Soria A, Hansen S, Dambietz C, Akbarzadeh M, Berg AF, Waetzig GH, Jones SA, Dvorsky R, Ahmadian MR, Scheller J, Moll JM. Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion. Sci Signal. 2021;14.

Henning C, Branopolski A, Follert P, Lewandowska O, Ayhan A, Benkhoff M, Flogel U, Kelm M, Heiss C, Lammert E. Endothelial beta1 Integrin-Mediated Adaptation to Myocardial Ischemia. Thromb Haemost. 2021;121:741-54.

Hesse J, Groterath W, Owenier C, Steinhausen J, Ding Z, Steckel B, Czekelius C, Alter C, Marzoq A, Schrader J. Normoxic induction of HIF-1alpha by adenosine-A2B R signaling in epicardial stromal cells formed after myocardial infarction. FASEB J. 2021;35:e21517.

Hesse J, Owenier C, Lautwein T, Zalfen R, Weber JF, Ding Z, Alter C, Lang A, Grandoch M, Gerdes N, Fischer JW, Klau GW, Dieterich C, Kohrer K, Schrader J. Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart. Elife. 2021;10.

Hesse J, Siekierka-Harreis M, Steckel B, Alter C, Schallehn M, Honke N, Schnieringer ML, Wippich M, Braband R, Schneider M, Surowy H, Wieczorek D, Schrader J, Pongratz G. Profound inhibition of CD73-dependent formation of anti-inflammatory adenosine in B cells of SLE patients. EBioMedicine. 2021;73:103616.

Heusch G. Myocardial stunning and hibernation revisited. Nat Rev Cardiol. 2021;18:522-36.

Heusch G, Rassaf T. Protection from cardiotoxicity of cancer chemotherapy: a novel target for remote ischaemic conditioning? Cardiovasc Res. 2021;117:985-6.

Hoermann H, Krueger I, Maurus N, Reusswig F, Sun Y, Kohlmorgen C, Grandoch M, Fischer JW, Elvers M. The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner. Int J Mol Sci. 2021;22.

Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andres V, Spyridopoulos I. Telomerase As a Therapeutic Target in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021;doi.org/10.1161/ATVBAHA.120.315695:ATVBAHA120315695.

Hundhausen C, Schneckmann R, Ostendorf Y, Rimpler J, von Glinski A, Kohlmorgen C, Pasch N, Rolauer L, von Ameln F, Eckermann O, Altschmied J, Ale-Agha N, Haendeler J, Flogel U, Fischer JW, Grandoch M. Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease. Matrix Biol. 2021;102:20-36.

Kerp H, Hones GS, Tolstik E, Hones-Wendland J, Gassen J, Moeller LC, Lorenz K, Fuhrer D. Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure. Front Cardiovasc Med. 2021;8:683522.

Kleinbongard P, Andreadou I, Vilahur G. The platelet paradox of injury versus protection in myocardial infarction-has it been overlooked? Basic Res Cardiol. 2021;116:37.

Koch D, Alexandrovich A, Funk F, Kho AL, Schmitt JP, Gautel M. Molecular noise filtering in the beta-adrenergic signaling network by phospholamban pentamers. Cell Rep. 2021;36:109448.

Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Kruger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flogel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M. Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus. Diabetologia. 2021;64:1834-49.

Kruger I, Reusswig F, Krott KJ, Lersch CF, Spelleken M, Elvers M. Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice. Int J Mol Sci. 2021;22.

Kupriyanova Y, Zaharia OP, Bobrov P, Karusheva Y, Burkart V, Szendroedi J, Hwang JH, Roden M, group GDS. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus. J Hepatol. 2021;74:1028-37.

Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021;12:3754.

Lecour S, Andreadou I, Botker HE, Davidson SM, Heusch G, Ruiz-Meana M, Schulz R, Zuurbier CJ, Ferdinandy P, Hausenloy DJ, on behalf of the European Union CCAC. IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action. Basic Res Cardiol. 2021;116:52.

Leo F, Suvorava T, Heuser SK, Li J, LoBue A, Barbarino F, Piragine E, Schneckmann R, Hutzler B, Good ME, Fernandez BO, Vornholz L, Rogers S, Doctor A, Grandoch M, Stegbauer J, Weitzberg E, Feelisch M, Lundberg JO, Isakson BE, Kelm M, Cortese-Krott MM. Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure. Circulation. 2021;144:870-89.

Lieder HR, Braczko F, Gedik N, Stroetges M, Heusch G, Kleinbongard P. Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes. Basic Res Cardiol. 2021;116:27.

M'Pembele R, Metzen D, Czychy N, Zako S, Mourikis P, Helten C, Trojovsky K, Ignatov D, Petzold T, Thienel M, Vornholz L, Bonner F, Levkau B, Zeus T, Kelm M, Dannenberg L, Polzin A. Diabetes mellitus is not associated with enhanced bleeding risk in patients after percutaneous coronary intervention. Diabet Med. 2021;38:e14532.

Mahdi A, Cortese-Krott MM, Kelm M, Li N, Pernow J. Novel perspectives on redox signaling in red blood cells and platelets in cardiovascular disease. Free Radic Biol Med. 2021;168:95-109.

Misiou A, Garmey JC, Hensien JM, Harmon DB, Osinski V, McSkimming C, Marshall MA, Fischer JW, Grandoch M, McNamara CA. Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation. Arterioscler Thromb Vasc Biol. 2021;41:796-807.

Muller E, Salcan S, Bongardt S, Barbosa DM, Kruger M, Kotter S. E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system. Sci Rep. 2021;11:21134.

Parco C, Brockmeyer M, Kosejian L, Quade J, Trostler J, Bader S, Lin Y, Karathanos A, Krieger T, Heinen Y, Schulze V, Icks A, Jung C, Kelm M, Wolff G. Modern NCDR and ACTION risk models outperform the GRACE model for prediction of in-hospital mortality in acute coronary syndrome in a German cohort. Int J Cardiol. 2021;329:28-35.

Polzin A, Helten C, Dannenberg L, Muller T, Graler M, Kelm M, Levkau B. Sphingosine-1-phosphate: A mediator of the ARB-MI paradox? Int J Cardiol. 2021;333:40-2.

Scheiber D, Zweck E, Albermann S, Jelenik T, Spieker M, Bonner F, Horn P, Schultheiss HP, Aleshcheva G, Escher F, Boeken U, Akhyari P, Roden M, Kelm M, Szendroedi J, Westenfeld R. Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection. ESC Heart Fail. 2021;8:4674-84.

Schneckmann R, Suvorava T, Hundhausen C, Schuler D, Lorenz C, Freudenberger T, Kelm M, Fischer JW, Flogel U, Grandoch M. Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling. Arterioscler Thromb Vasc Biol. 2021;41:2551-62.

Temme S, Yakoub M, Bouvain P, Yang G, Schrader J, Stegbauer J, Flogel U. Beyond Vessel Diameters: Non-invasive Monitoring of Flow Patterns and Immune Cell Recruitment in Murine Abdominal Aortic Disorders by Multiparametric MRI. Front Cardiovasc Med. 2021;8:750251.

Vornholz L, Nienhaus F, Gliem M, Alter C, Henning C, Lang A, Ezzahoini H, Wolff G, Clasen L, Rassaf T, Flogel U, Kelm M, Gerdes N, Jander S, Bonner F. Acute Heart Failure After Reperfused Ischemic Stroke: Association With Systemic and Cardiac Inflammatory Responses. Front Physiol. 2021;12:782760.

Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E, Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-Armouche A, Sossalla S, Kammerer S. Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression. Int J Mol Sci. 2021;22.

Wischmann P, Chennupati R, Solga I, Funk F, Becher S, Gerdes N, Anker S, Kelm M, Jung C. Safety and efficacy of iron supplementation after myocardial infarction in mice with moderate blood loss anaemia. ESC Heart Fail. 2021;8:5445-55.

Xiao Y, Phelp P, Wang Q, Bakker D, Nederlof R, Hollmann MW, Zuurbier CJ. Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol. Front Cardiovasc Med. 2021;8:712478.

Xiao Y, Yim K, Zhang H, Bakker D, Nederlof R, Smeitink JAM, Renkema H, Hollmann MW, Weber NC, Zuurbier CJ. The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury. Cardiovasc Drugs Ther. 2021;35:745-58.

Zweck E, Scheiber D, Jelenik T, Bonner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, Kelm M, Roden M, Westenfeld R, Szendroedi J. Exposure to Type 2 Diabetes Provokes Mitochondrial Impairment in Apparently Healthy Human Hearts. Diabetes Care. 2021;44:e82-e4.

Zweck E, Thayer KL, Helgestad OKL, Kanwar M, Ayouty M, Garan AR, Hernandez-Montfort J, Mahr C, Wencker D, Sinha SS, Vorovich E, Abraham J, O'Neill W, Li S, Hickey GW, Josiassen J, Hassager C, Jensen LO, Holmvang L, Schmidt H, Ravn HB, Moller JE, Burkhoff D, Kapur NK. Phenotyping Cardiogenic Shock. J Am Heart Assoc. 2021;10:e020085.

 

 

Andreadou I, Schulz R, Badimon L, Adameova A, Kleinbongard P, Lecour S, Nikolaou PE, Falcao-Pires I, Vilahur G, Woudberg N, Heusch G, Ferdinandy P. Hyperlipidaemia and cardioprotection: Animal models for translational studies. Br J Pharmacol. 2020;177:5287-311.

Barbosa DM, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al-Hasani H, Kruger M, Ouwens DM, Hartwig S, Lehr S, Kotzka J, Knebel B. Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis. Sci Rep. 2020;10:4888.

Botker HE, Cabrera-Fuentes HA, Ruiz-Meana M, Heusch G, Ovize M. Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST-segment elevation myocardial infarction. J Cell Mol Med. 2020;24:2717-29.

Bouvain P, Temme S, Flogel U. Hot spot (19) F magnetic resonance imaging of inflammation. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020;12:e1639.

Bruno RR, Kelm M, Jung C. Spotlight on comorbidities in STEMI patients. Endocrinol Diabetes Metab. 2020;3:e00102.

Burnap SA, Joshi A, Tsimikas S, Fernandez-Hernando C, Kiechl S, Berry SE, Hall W, Levkau B, Mayr M. High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation. J Am Coll Cardiol. 2020;75:1495-7.

Dannenberg L, Metzen D, Zako S, Pohl M, Mourikis P, Helten C, Trojovsky K, Naguib D, Konsek D, Knoop B, Ayhan A, Hohlfeld T, Petzold T, Levkau B, Veulemans V, Zeus T, Kelm M, Polzin A. Enhanced Platelet Reactivity under Aspirin Medication and Major Adverse Cardiac and Cerebrovascular Events in Patients with Coronary Artery Disease. Pharmacology. 2020;105:118-22.

Dannenberg L, Zikeli D, Benkhoff M, Ahlbrecht S, Kelm M, Levkau B, Polzin A. Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy. Pharmacol Ther. 2020;213:107584.

Dao VT, Elbatreek MH, Deile M, Nedvetsky PI, Guldner A, Ibarra-Alvarado C, Godecke A, Schmidt H. Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease. Sci Rep. 2020;10:10012.

Del Monte-Nieto G, Fischer JW, Gorski DJ, Harvey RP, Kovacic JC. Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar. J Am Coll Cardiol. 2020;75:2169-88.

Donner L, Toska LM, Kruger I, Groniger S, Barroso R, Burleigh A, Mezzano D, Pfeiler S, Kelm M, Gerdes N, Watson SP, Sun Y, Elvers M. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of beta-amyloid. Sci Signal. 2020;13.

Helten C, Mourikis P, Dannenberg L, M'Pembele R, Trojovsky K, Ayhan A, Kohlmorgen C, Grandoch M, Levkau B, Veulemans V, Petzold T, Hohlfeld T, Kelm M, Zeus T, Polzin A. A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox? Eur J Clin Pharmacol. 2020;76:1245-51.

Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol. 2020;17:773-89.

Heusch G, Gersh BJ. Is Cardioprotection Salvageable? Circulation. 2020;141:415-7.

Heusch G, Kleinbongard P. Is metoprolol more cardioprotective than other beta-blockers? Eur Heart J. 2020;41:4441-3.

Heusch G, Rassaf T. Left Ventricular Unloading in Myocardial Infarction: Gentle Reperfusion Through the Backdoor? J Am Coll Cardiol. 2020;76:700-2.

Kleinbongard P. Cardioprotection by early metoprolol- attenuation of ischemic vs. reperfusion injury? Basic Res Cardiol. 2020;115:54.

Kleinbongard P, Botker HE, Ovize M, Hausenloy DJ, Heusch G. Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? Br J Pharmacol. 2020;177:5252-69.

Klose AM, Klier M, Gorressen S, Elvers M. Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction. Int J Mol Sci. 2020;21.

Klymenko O, Brecklinghaus T, Dille M, Springer C, de Wendt C, Altenhofen D, Binsch C, Knebel B, Scheller J, Hardt C, Herwig R, Chadt A, Pfluger PT, Al-Hasani H, Kabra DG. Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle. Mol Metab. 2020;42:101062.

Krueger I, Gremer L, Mangels L, Klier M, Jurk K, Willbold D, Bock HH, Elvers M. Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases. Arterioscler Thromb Vasc Biol. 2020;40:2391-403.

Kruger N, Biwer LA, Good ME, Ruddiman CA, Wolpe AG, DeLalio LJ, Murphy S, Macal EH, Jr., Ragolia L, Serbulea V, Best AK, Leitinger N, Harris TE, Sonkusare SK, Godecke A, Isakson BE. Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. Circ Res. 2020;126:232-42.

Kunzel SR, Rausch JSE, Schaffer C, Hoffmann M, Kunzel K, Klapproth E, Kant T, Herzog N, Kupper JH, Lorenz K, Dudek S, Emig R, Ravens U, Rog-Zielinska EA, Peyronnet R, El-Armouche A. Modeling atrial fibrosis in vitro-Generation and characterization of a novel human atrial fibroblast cell line. FEBS Open Bio. 2020;10:1210-8.

Loescher CM, Breitkreuz M, Li Y, Nickel A, Unger A, Dietl A, Schmidt A, Mohamed BA, Kotter S, Schmitt JP, Kruger M, Kruger M, Toischer K, Maack C, Leichert LI, Hamdani N, Linke WA. Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx). Proc Natl Acad Sci U S A. 2020;117:24545-56.

Mourikis P, Zako S, Dannenberg L, Helten C, Naguib D, Hohlfeld T, Petzold T, Levkau B, Zeus T, Kelm M, Polzin A. Aspirin antiplatelet effects are associated with body weight. Vascul Pharmacol. 2020;125-126:106635.

Muessig JM, Kaya S, Moellhoff L, Noelle J, Hidalgo Pareja L, Masyuk M, Gerdes N, Pernow J, Kelm M, Jung C. A Model of Blood Component-Heart Interaction in Cardiac Ischemia-Reperfusion Injury using a Langendorff-Based Ex Vivo Assay. J Cardiovasc Pharmacol Ther. 2020;25:164-73.

Muessig JM, Moellhoff L, Noelle J, Kaya S, Hidalgo Pareja L, Masyuk M, Roden M, Kelm M, Jung C. Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury. Nitric Oxide. 2020;97:1-10.

Ottolini M, Hong K, Cope EL, Daneva Z, DeLalio LJ, Sokolowski JD, Marziano C, Nguyen NY, Altschmied J, Haendeler J, Johnstone SR, Kalani MY, Park MS, Patel RP, Liedtke W, Isakson BE, Sonkusare SK. Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. Circulation. 2020;141:1318-33.

Petzold T, Dannenberg L, Thienel M, Ahlbrecht S, Mourikis P, Helten C, M'Pembele R, Achilles A, Zikeli D, Zhang Z, Lusebrink E, Nicolai L, Saleh I, Jung C, Gerdes N, Hoffmann T, Levkau B, Hohlfeld T, Zeus T, Schulz C, Kelm M, Polzin A. Response by Petzold et al to Letter Regarding Article, "Rivaroxaban Reduces Arterial Thrombosis by Inhibition of Fxa-Driven Platelet Activation via Protease Activated Receptor-1". Circ Res. 2020;126:e116-e7.

Petzold T, Thienel M, Dannenberg L, Mourikis P, Helten C, Ayhan A, M'Pembele R, Achilles A, Trojovky K, Konsek D, Zhang Z, Regenauer R, Pircher J, Ehrlich A, Lusebrink E, Nicolai L, Stocker TJ, Brandl R, Roschenthaler F, Strecker J, Saleh I, Spannagl M, Mayr CH, Schiller HB, Jung C, Gerdes N, Hoffmann T, Levkau B, Hohlfeld T, Zeus T, Schulz C, Kelm M, Polzin A. Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1. Circ Res. 2020;126:486-500.

Petzold T, Thienel M, Dannenberg L, Mourikis P, Helten C, Ayhan A, M'Pembele R, Achilles A, Trojovky K, Zhang Z, Regenauer R, Pircher J, Ehrlich A, Lusebrink E, Nicolai L, Stocker TJ, Brandl R, Roschenthaler F, Strecker J, Saleh I, Spannagl M, Mayr CH, Schiller HB, Jung C, Gerdes N, Hoffmann T, Levkau B, Hohlfeld T, Zeus T, Schulz C, Kelm M, Polzin A. Response by Petzold et al to Letter Regarding Article, "Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1". Circ Res. 2020;126:e54-e5.

Raje V, Ahern KW, Martinez BA, Howell NL, Oenarto V, Granade ME, Kim JW, Tundup S, Bottermann K, Godecke A, Keller SR, Kadl A, Bland ML, Harris TE. Adipocyte lipolysis drives acute stress-induced insulin resistance. Sci Rep. 2020;10:18166.

Rosen J, Jakobs P, Ale-Agha N, Altschmied J, Haendeler J. Non-canonical functions of Telomerase Reverse Transcriptase - Impact on redox homeostasis. Redox Biol. 2020;34:101543.

Salcan S, Bongardt S, Monteiro Barbosa D, Efimov IR, Rassaf T, Kruger M, Kotter S. Elastic titin properties and protein quality control in the aging heart. Biochim Biophys Acta Mol Cell Res. 2020;1867:118532.

Sarabhai T, Kahl S, Szendroedi J, Markgraf DF, Zaharia OP, Barosa C, Herder C, Wickrath F, Bobrov P, Hwang JH, Jones JG, Roden M. Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance. JCI Insight. 2020;5.

Schwerd T, Krause F, Twigg SRF, Aschenbrenner D, Chen YH, Borgmeyer U, Muller M, Manrique S, Schumacher N, Wall SA, Jung J, Damm T, Gluer CC, Scheller J, Rose-John S, Jones EY, Laurence A, Wilkie AOM, Schmidt-Arras D, Uhlig HH. A variant in IL6ST with a selective IL-11 signaling defect in human and mouse. Bone Res. 2020;8:24.

Staal AHJ, Becker K, Tagit O, Koen van Riessen N, Koshkina O, Veltien A, Bouvain P, Cortenbach KRG, Scheenen T, Flogel U, Temme S, Srinivas M. In vivo clearance of (19)F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure. Biomaterials. 2020;261:120307.

Straub T, Nave J, Bouvain P, Akbarzadeh M, Dasa SSK, Kistner J, Ding Z, Marzoq A, Stepanow S, Becker K, Hesse J, Kohrer K, Flogel U, Ahmadian MR, French BA, Schrader J, Temme S. MRI-based molecular imaging of epicardium-derived stromal cells (EpiSC) by peptide-mediated active targeting. Sci Rep. 2020;10:21669.

Swain L, Reyelt L, Bhave S, Qiao X, Thomas CJ, Zweck E, Crowley P, Boggins C, Esposito M, Chin M, Karas RH, O'Neill W, Kapur NK. Transvalvular Ventricular Unloading Before Reperfusion in Acute Myocardial Infarction. J Am Coll Cardiol. 2020;76:684-99.

Tomasovic A, Brand T, Schanbacher C, Kramer S, Hummert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knuchel R, Muller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Muller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects. Nat Commun. 2020;11:1733.

Wang X, Temme S, Grapentin C, Palasubramaniam J, Walsh A, Kramer W, Kleimann P, Havlas A, Schubert R, Schrader J, Flogel U, Peter K. Fluorine-19 Magnetic Resonance Imaging of Activated Platelets. J Am Heart Assoc. 2020;9:e016971.

Wernly B, Pernow J, Kelm M, Jung C. The role of arginase in the microcirculation in cardiovascular disease. Clin Hemorheol Microcirc. 2020;74:79-92.

Wischmann P, Kuhn V, Suvorava T, Muessig JM, Fischer JW, Isakson BE, Haberkorn SM, Flogel U, Schrader J, Jung C, Cortese-Krott MM, Heusch G, Kelm M. Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia. Basic Res Cardiol. 2020;115:43.

Wu W, Wang X, Berleth N, Deitersen J, Wallot-Hieke N, Bohler P, Schlutermann D, Stuhldreier F, Cox J, Schmitz K, Seggewiss S, Peter C, Kasof G, Stefanski A, Stuhler K, Tschapek A, Godecke A, Stork B. The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death. Cell Rep. 2020;31:107547.

Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ. NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart. Front Immunol. 2020;11:591815.

 

Alter C, Ding Z, Flogel U, Scheller J, Schrader J. A2bR-dependent signaling alters immune cell composition and enhances IL-6 formation in the ischemic heart. Am J Physiol Heart Circ Physiol. 2019;317:H190-H200.

Amanakis G, Kleinbongard P, Heusch G, Skyschally A. Attenuation of ST-segment elevation after ischemic conditioning maneuvers reflects cardioprotection online. Basic Res Cardiol. 2019;114:22.

Bouvain P, Flocke V, Kramer W, Schubert R, Schrader J, Flogel U, Temme S. Dissociation of (19)F and fluorescence signal upon cellular uptake of dual-contrast perfluorocarbon nanoemulsions. MAGMA. 2019;32:133-45.

Breitenbach T, Lorenz K, Dandekar T. How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency. Int J Mol Sci. 2019;20.

Dannenberg L, Wolff G, Naguib D, Pohl M, Zako S, Helten C, Mourikis P, Levkau B, Hohlfeld T, Zeus T, Kelm M, Schulze V, Polzin A. Safety and efficacy of Tirofiban in STEMI-patients. Int J Cardiol. 2019;274:35-9.

Davidson SM, Ferdinandy P, Andreadou I, Botker HE, Heusch G, Ibanez B, Ovize M, Schulz R, Yellon DM, Hausenloy DJ, Garcia-Dorado D, Action CC. Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week. J Am Coll Cardiol. 2019;73:89-99.

Fischer JW. Role of hyaluronan in atherosclerosis: Current knowledge and open questions. Matrix Biol. 2019;78-79:324-36.

Frey UH, Klaassen M, Ochsenfarth C, Murke F, Thielmann M, Kottenberg E, Kleinbongard P, Klenke S, Engler A, Heusch G, Giebel B, Peters J. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients. Acta Anaesthesiol Scand. 2019;63:483-92.

Gonnissen S, Ptok J, Goy C, Jander K, Jakobs P, Eckermann O, Kaisers W, von Ameln F, Timm J, Ale-Agha N, Haendeler J, Schaal H, Altschmied J. High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells. Oxid Med Cell Longev. 2019;2019:7976382.

Gorski DJ, Petz A, Reichert C, Twarock S, Grandoch M, Fischer JW. Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance. Sci Rep. 2019;9:1827.

Grandoch M, Flogel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castaneda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sorgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW. 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab. 2019;1:546-59.

Hausenloy DJ, Botker HE, Ferdinandy P, Heusch G, Ng GA, Redington A, Garcia-Dorado D. Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection. Cardiovasc Res. 2019;115:1167-77.

Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G. The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection. Cardiovasc Res. 2019;115:1143-55.

Hausenloy DJ, Heusch G. Translating Cardioprotection for Patient Benefit: The EU-CARDIOPROTECTION COST Action. J Am Coll Cardiol. 2019;73:2001-3.

Heinen A, Nederlof R, Panjwani P, Spychala A, Tschaidse T, Reffelt H, Boy J, Raupach A, Godecke S, Petzsch P, Kohrer K, Grandoch M, Petz A, Fischer JW, Alter C, Vasilevska J, Lang P, Godecke A. IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells. Mol Ther. 2019;27:46-58.

Henning C, Branopolski A, Schuler D, Dimitroulis D, Huelsemann P, Nicolaus C, Sansone R, Ludolf Postma J, Eberhard D, Le Noble F, Kelm M, Lammert E, Heiss C. Requirement of beta1 integrin for endothelium-dependent vasodilation and collateral formation in hindlimb ischemia. Sci Rep. 2019;9:16931.

Henninger C, Pohlmann S, Ziegler V, Ohlig J, Schmitt J, Fritz G. Distinct contribution of Rac1 expression in cardiomyocytes to anthracycline-induced cardiac injury. Biochem Pharmacol. 2019;164:82-93.

Heusch G. The Spleen in Myocardial Infarction. Circ Res. 2019;124:26-8.

Heusch G. Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol. 2019;114:45.

Heusch G. Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what? Am J Physiol Heart Circ Physiol. 2019;316:H1439-H46.

Heusch G, Kleinbongard P, Rassaf T. Cardioprotection Beyond Infarct Size Reduction. Circ Res. 2019;124:679-80.

Jochmann S, Elkenani M, Mohamed BA, Buchholz E, Lbik D, Binder L, Lorenz K, Shah AM, Hasenfuss G, Toischer K, Schnelle M. Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling. ESC Heart Fail. 2019;6:1015-26.

Keul P, Polzin A, Kaiser K, Graler M, Dannenberg L, Daum G, Heusch G, Levkau B. Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB J. 2019;33:1482-95.

Knoop B, Naguib D, Dannenberg L, Helten C, Zako S, Jung C, Levkau B, Grandoch M, Kelm M, Zeus T, Polzin A. Cardioprotection by very mild hypothermia in mice. Cardiovasc Diagn Ther. 2019;9:64-7.

Kramer W, Grapentin C, Bouvain P, Temme S, Flogel U, Schubert R. Rational manufacturing of functionalized, long-term stable perfluorocarbon-nanoemulsions for site-specific (19)F magnetic resonance imaging. Eur J Pharm Biopharm. 2019;142:114-22.

Kruger M. Remote ischemic preconditioning and beyond-are we getting closer to the secret of cardioprotection? Pflugers Arch. 2019;471:1369-70.

Lieder HR, Irmert A, Kamler M, Heusch G, Kleinbongard P. Sex is no determinant of cardioprotection by ischemic preconditioning in rats, but ischemic/reperfused tissue mass is for remote ischemic preconditioning. Physiol Rep. 2019;7:e14146.

Lieder HR, Skyschally A, Heusch G, Kleinbongard P. Plasma from remotely conditioned pigs reduces infarct size when given before or after ischemia to isolated perfused rat hearts. Pflugers Arch. 2019;471:1371-9.

Maimari T, Krasel C, Bunemann M, Lorenz K. The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on beta-adrenoceptors. Biochem Biophys Res Commun. 2019;520:327-32.

Nagy N, Gurevich I, Kuipers HF, Ruppert SM, Marshall PL, Xie BJ, Sun W, Malkovskiy AV, Rajadas J, Grandoch M, Fischer JW, Frymoyer AR, Kaber G, Bollyky PL. 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. J Biol Chem. 2019;294:7864-77.

Nienhaus F, Colley D, Jahn A, Pfeiler S, Flocke V, Temme S, Kelm M, Gerdes N, Flogel U, Bonner F. Phagocytosis of a PFOB-Nanoemulsion for (19)F Magnetic Resonance Imaging: First Results in Monocytes of Patients with Stable Coronary Artery Disease and ST-Elevation Myocardial Infarction. Molecules. 2019;24.

Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth M, Schneckmann R, Homann S, Muller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kotter S, Kruger M, Heinen A, Kelm M, Godecke A, Flogel U, Fischer JW. Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury. Circ Res. 2019;124:1433-47.

Rothe M, Jahn A, Weiss K, Hwang JH, Szendroedi J, Kelm M, Schrader J, Roden M, Flogel U, Bonner F. In vivo (19)F MR inflammation imaging after myocardial infarction in a large animal model at 3 T. MAGMA. 2019;32:5-13.

Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J. High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med. 2019;51:1-10.

Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M, Roden M, Szendroedi J, Westenfeld R. Reduced Myocardial Mitochondrial ROS Production in Mechanically Unloaded Hearts. J Cardiovasc Transl Res. 2019;12:107-15.

Schrage B, Ibrahim K, Loehn T, Werner N, Sinning JM, Pappalardo F, Pieri M, Skurk C, Lauten A, Landmesser U, Westenfeld R, Horn P, Pauschinger M, Eckner D, Twerenbold R, Nordbeck P, Salinger T, Abel P, Empen K, Busch MC, Felix SB, Sieweke JT, Moller JE, Pareek N, Hill J, MacCarthy P, Bergmann MW, Henriques JPS, Mobius-Winkler S, Schulze PC, Ouarrak T, Zeymer U, Schneider S, Blankenberg S, Thiele H, Schafer A, Westermann D. Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock. Circulation. 2019;139:1249-58.

Skyschally A, Hagelschuer H, Kleinbongard P, Heusch G. Larger infarct size but equal protection by ischemic conditioning in septum and anterior free wall of pigs with LAD occlusion. Physiol Rep. 2019;7:e14236.

Stoian L, Kruger M, Schmitt J, Kleinbongard P. Is there an effect of ischemic conditioning on myocardial contractile function following acute myocardial ischemia/reperfusion injury? Biochim Biophys Acta Mol Basis Dis. 2019;1865:822-30.

Uthman L, Nederlof R, Eerbeek O, Baartscheer A, Schumacher C, Buchholtz N, Hollmann MW, Coronel R, Weber NC, Zuurbier CJ. Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts. Cardiovasc Res. 2019;115:1533-45.

Vaidya M, Jentsch JA, Peters S, Keul P, Weske S, Graler MH, Mladenov E, Iliakis G, Heusch G, Levkau B. Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res. 2019;60:506-15.

Wernly B, Fuernau G, Masyuk M, Muessig JM, Pfeiler S, Bruno RR, Desch S, Muench P, Lichtenauer M, Kelm M, Adams V, Thiele H, Eitel I, Jung C. Syndecan-1 Predicts Outcome in Patients with ST-Segment Elevation Infarction Independent from Infarct-related Myocardial Injury. Sci Rep. 2019;9:18367.

Weske S, Vaidya M, von Wnuck Lipinski K, Keul P, Manthe K, Burkhart C, Haberhauer G, Heusch G, Levkau B. Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice. Bone. 2019;125:1-7.

Zaharia OP, Strassburger K, Strom A, Bonhof GJ, Karusheva Y, Antoniou S, Bodis K, Markgraf DF, Burkart V, Mussig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Haring HU, Ziegler D, Kuss O, Szendroedi J, Roden M, German Diabetes Study G. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol. 2019;7:684-94.

Zweck E, Roden M. GLP-1 receptor agonists and cardiovascular disease: drug-specific or class effects? Lancet Diabetes Endocrinol. 2019;7:89-90.

Zweck E, Westenfeld R, Szendroedi J. Oral Semaglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;381:2075-6.

Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Kohrer K, Deenen R, Unfried K, Altschmied J and Haendeler J. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. PLoS Biol. 2018;16:e2004408.

Bianco CL, Savitsky A, Feelisch M and Cortese-Krott MM. Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells. Biochem Pharmacol. 2018;149:163-173.

Cortese-Krott MM, Mergia E, Kramer CM, Luckstadt W, Yang J, Wolff G, Panknin C, Bracht T, Sitek B, Pernow J, Stasch JP, Feelisch M, Koesling D and Kelm M. Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease. Redox Biol. 2018;14:328-337.

Diederich L, Suvorava T, Sansone R, Keller TCSt, Barbarino F, Sutton TR, Kramer CM, Luckstadt W, Isakson BE, Gohlke H, Feelisch M, Kelm M and Cortese-Krott MM. On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability. Front Physiol. 2018;9:332.

Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flogel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM and Scheller J. IL-23R Signaling Plays No Role in Myocardial Infarction. Sci Rep. 2018;8:17078.

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floss DM, Lang PA and Scheller J. Synthetic cytokine receptors transmit biological signals using artificial ligands. Nat Commun. 2018;9:2034.

Erkens R, Suvorava T, Sutton TR, Fernandez BO, Mikus-Lelinska M, Barbarino F, Flogel U, Kelm M, Feelisch M and Cortese-Krott MM. Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection. Oxid Med Cell Longev. 2018;2018:8309698.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klocker N and Trauner D. Optical control of L-type Ca(2+) channels using a diltiazem photoswitch. Nat Chem Biol. 2018;14:764-767.

Grandoch M, Bollyky PL and Fischer JW. Hyaluronan: A Master Switch Between Vascular Homeostasis and Inflammation. Circ Res. 2018;122:1341-1343.

Heinen A, Behmenburg F, Aytulun A, Dierkes M, Zerbin L, Kaisers W, Schaefer M, Meyer-Treschan T, Feit S, Bauer I, Hollmann MW and Huhn R. The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent. J Transl Med. 2018;16:112.

Heinen A, Raupach A, Behmenburg F, Holscher N, Flogel U, Kelm M, Kaisers W, Nederlof R, Huhn R and Godecke A. Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method. Ultrasound Med Biol. 2018;44:1544-1555.

Heiss C, Spyridopoulos I and Haendeler J. Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol. 2018;109:108-118.

Hendgen-Cotta UB, Esfeld S, Jastrow H, Totzeck M, Altschmied J, Goy C, Haendeler J, Winterhager E and Rassaf T. Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations. Mitochondrion. 2018;38:1-5.

Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P and Fischer JW. Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biol. 2018;66:67-80.

Hopf AE, Andresen C, Kotter S, Isic M, Ulrich K, Sahin S, Bongardt S, Roll W, Drove F, Scheerer N, Vandekerckhove L, De Keulenaer GW, Hamdani N, Linke WA and Kruger M. Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1. Circ Res. 2018;123:342-355.

Jelenik T, Dille M, Muller-Luhlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H and Castaneda TR. FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab. 2018;16:126-138.

Jelenik T, Flogel U, Alvarez-Hernandez E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Muller-Wieland D, Moellendorf S, Godecke A, Kelm M, Westenfeld R, Roden M and Szendroedi J. Insulin Resistance and Vulnerability to Cardiac Ischemia. Diabetes. 2018;67:2695-2702.

Klatt C, Kruger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Luckstadt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M and Elvers M. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest. 2018;128:3906-3925.

Kleinbongard P, Amanakis G, Skyschally A and Heusch G. Reflection of Cardioprotection by Remote Ischemic Perconditioning in Attenuated ST-Segment Elevation During Ongoing Coronary Occlusion in Pigs: Evidence for Cardioprotection From Ischemic Injury. Circ Res. 2018;122:1102-1108.

Kleinbongard P, Peters J, Jakob H, Heusch G and Thielmann M. Persistent Survival Benefit From Remote Ischemic Pre-Conditioning in Patients Undergoing Coronary Artery Bypass Surgery. J Am Coll Cardiol. 2018;71:252-254.

Kleinbongard P, Skyschally A, Gent S, Pesch M and Heusch G. STAT3 as a common signal of ischemic conditioning: a lesson on "rigor and reproducibility" in preclinical studies on cardioprotection. Basic Res Cardiol. 2018;113:3.

Klier M, Gorressen S, Urbahn MA, Barbosa D, Ouwens M, Fischer JW and Elvers M. Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-alpha Regulation and Myocardial Healing. Front Physiol. 2018;9:1698.

Kronenbitter A, Funk F, Hackert K, Gorressen S, Glaser D, Boknik P, Poschmann G, Stuhler K, Isic M, Kruger M and Schmitt JP. Impaired Ca(2+) cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction. J Mol Cell Cardiol. 2018;119:28-39.

Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N and Lutgens E. CD40L Deficiency Protects Against Aneurysm Formation. Arterioscler Thromb Vasc Biol. 2018;38:1076-1085.

Mafakheri S, Chadt A and Al-Hasani H. Regulation of RabGAPs involved in insulin action. Biochem Soc Trans. 2018;46:683-690.

Michaud SA, Sinclair NJ, Petrosova H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y, Eshghi A, Richard VR, Sickmann A and Borchers CH. Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Commun Biol. 2018;1:78.

Nguyen TD, Schwarzer M, Schrepper A, Amorim PA, Blum D, Hain C, Faerber G, Haendeler J, Altschmied J and Doenst T. Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts. J Am Heart Assoc. 2018;7.

Olson KR, Gao Y, Arif F, Arora K, Patel S, DeLeon ER, Sutton TR, Feelisch M, Cortese-Krott MM and Straub KD. Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase. Redox Biol. 2018;15:74-85.

Sansone R, Baaken M, Horn P, Schuler D, Westenfeld R, Amabile N, Kelm M and Heiss C. Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease. Data Brief. 2018;19:495-500.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts S, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slutter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C and Lutgens E. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018;71:527-542.

Skyschally A, Kleinbongard P, Lieder H, Gedik N, Stoian L, Amanakis G, Elbers E and Heusch G. Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice. Am J Physiol Heart Circ Physiol. 2018;315:H159-H172.

Spieker M, Katsianos E, Gastl M, Behm P, Horn P, Jacoby C, Schnackenburg B, Reinecke P, Kelm M, Westenfeld R and Bonner F. T2 mapping cardiovascular magnetic resonance identifies the presence of myocardial inflammation in patients with dilated cardiomyopathy as compared to endomyocardial biopsy. Eur Heart J Cardiovasc Imaging. 2018;19:574-582.

Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, Wischmann P, Madhani M, Frenneaux MP, Postle AD, Cortese-Krott MM and Feelisch M. A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Redox Biol. 2018;16:359-380.

Tura A, Chemello G, Szendroedi J, Gobl C, Faerch K, Vrbikova J, Pacini G, Ferrannini E and Roden M. Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index. Diabetologia. 2018;61:1135-1141.

Urbahn MA, Kaup SC, Reusswig F, Kruger I, Spelleken M, Jurk K, Klier M, Lang PA and Elvers M. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep. 2018;8:10006.

van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC, Jr., Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ and Houten SM. Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B. Cardiovasc Res. 2018;114:1324-1334.

Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer JK, Fischer JW, Flogel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dorr M, Volzke H, Moritz E, Hannemann A, Rauch BH, Graler MH, Heusch G and Levkau B. Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat Med. 2018;24:667-678.

 

Achilles A, Mohring A, Dannenberg L, Grandoch M, Hohlfeld T, Fischer JW, Levkau B, Kelm M, Zeus T and Polzin A. Dabigatran enhances platelet reactivity and platelet thrombin receptor expression in patients with atrial fibrillation. J Thromb Haemost. 2017;15:473-476.

Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP and Sickmann A. Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood. 2017;129:e1-e12.

Behmenburg F, Holscher N, Flogel U, Hollmann MW, Heinen A and Huhn R. Opening of calcium-activated potassium channels improves long-term left-ventricular function after coronary artery occlusion in mice. Int J Cardiol. 2017;241:351-357.

Binsch C, Jelenik T, Pfitzer A, Dille M, Muller-Luhlhoff S, Hartwig S, Karpinski S, Lehr S, Kabra DG, Chadt A, Roden M, Al-Hasani H and Castaneda TR. Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress. Mol Metab. 2017;6:1443-1453.

Boege F, Westenfeld R and Jahns R. beta1AAb Determined by Peptide ELISA: A Signal in the Noise? J Am Coll Cardiol. 2017;70:807-808.

Borg N, Alter C, Gorldt N, Jacoby C, Ding Z, Steckel B, Quast C, Bonner F, Friebe D, Temme S, Flogel U and Schrader J. CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming. Circulation. 2017;136:297-313.

Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR and Feelisch M. The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. Antioxid Redox Signal. 2017;27:684-712.

Dyballa-Rukes N, Jakobs P, Eckers A, Ale-Agha N, Serbulea V, Aufenvenne K, Zschauer TC, Rabanter LL, Jakob S, von Ameln F, Eckermann O, Leitinger N, Goy C, Altschmied J and Haendeler J. The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1. Antioxid Redox Signal. 2017;26:616-629.

Erkens R, Suvorava T, Kramer CM, Diederich LD, Kelm M and Cortese-Krott MM. Modulation of Local and Systemic Heterocellular Communication by Mechanical Forces: A Role of Endothelial Nitric Oxide Synthase. Antioxid Redox Signal. 2017;26:917-935.

Floss DM, Schonberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM and Scheller J. IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling. Sci Rep. 2017;7:15172.

Gedik N, Kottenberg E, Thielmann M, Frey UH, Jakob H, Peters J, Heusch G and Kleinbongard P. Potential humoral mediators of remote ischemic preconditioning in patients undergoing surgical coronary revascularization. Sci Rep. 2017;7:12660.

Gedik N, Kruger M, Thielmann M, Kottenberg E, Skyschally A, Frey UH, Cario E, Peters J, Jakob H, Heusch G and Kleinbongard P. Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion: remote ischemic preconditioning. Sci Rep. 2017;7:7629.

Gedik N, Maciel L, Schulte C, Skyschally A, Heusch G and Kleinbongard P. Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning. Arch Med Sci. 2017;13:448-458.

Godecke A and Haendeler J. Intra- and Interorgan Communication in the Cardiovascular System: A Special View on Redox Regulation. Antioxid Redox Signal. 2017;26:613-615.

Gowert NS, Kruger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Kober S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH and Elvers M. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017;40:210-221.

Haberkorn SM, Jacoby C, Ding Z, Keul P, Bonner F, Polzin A, Levkau B, Schrader J, Kelm M and Flogel U. Cardiovascular Magnetic Resonance Relaxometry Predicts Regional Functional Outcome After Experimental Myocardial Infarction. Circ Cardiovasc Imaging. 2017;10.

Hendgen-Cotta UB, Esfeld S, Coman C, Ahrends R, Klein-Hitpass L, Flogel U, Rassaf T and Totzeck M. A novel physiological role for cardiac myoglobin in lipid metabolism. Sci Rep. 2017;7:43219.

Hernandez EA, Kahl S, Seelig A, Begovatz P, Irmler M, Kupriyanova Y, Nowotny B, Nowotny P, Herder C, Barosa C, Carvalho F, Rozman J, Neschen S, Jones JG, Beckers J, de Angelis MH and Roden M. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest. 2017;127:695-708.

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J and Schrader J. CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction. FASEB J. 2017;31:3040-3053.

Heusch G. Critical Issues for the Translation of Cardioprotection. Circ Res. 2017;120:1477-1486.

Heusch G. Remote ischemic conditioning: the enigmatic transfer of protection. Cardiovasc Res. 2017;113:1-2.

Hilfiker-Kleiner D, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kindermann I, Kuhl U, Angermann CE, Schlitt A, Fischer D, Podewski E, Bohm M, Sliwa K and Bauersachs J. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J. 2017;38:2671-2679.

Hummel TM, Ackfeld T, Schonberg M, Ciupka G, Schulz F, Oberdoerster A, Grotzinger J, Scheller J and Floss DM. Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol. 2017;37.

Jelenik T, Kaul K, Sequaris G, Flogel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Horbelt T, Lehr S, Reinbeck AL, Muller-Wieland D, Esposito I, Shulman GI, Szendroedi J and Roden M. Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes. 2017;66:2241-2253.

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klocker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO and Meyer C. Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun. 2017;8:14155.

Kahlert P, Hildebrandt HA, Patsalis PC, Al-Rashid F, Janosi RA, Nensa F, Schlosser TW, Schlamann M, Wendt D, Thielmann M, Kottenberg E, Frey U, Neuhauser M, Forsting M, Jakob HG, Rassaf T, Peters J, Heusch G and Kleinbongard P. No protection of heart, kidneys and brain by remote ischemic preconditioning before transfemoral transcatheter aortic valve implantation: Interim-analysis of a randomized single-blinded, placebo-controlled, single-center trial. Int J Cardiol. 2017;231:248-254.

Keller AS, Diederich L, Panknin C, DeLalio LJ, Drake JC, Sherman R, Jackson EK, Yan Z, Kelm M, Cortese-Krott MM and Isakson BE. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017;313:C593-C603.

Kleinbongard P, Skyschally A and Heusch G. Cardioprotection by remote ischemic conditioning and its signal transduction. Pflugers Arch. 2017;469:159-181.

Klier M, Gowert NS, Jackel S, Reinhardt C and Elvers M. Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal. 2017;38:171-181.

Kuhn V, Diederich L, Keller TCSt, Kramer CM, Luckstadt W, Panknin C, Suvorava T, Isakson BE, Kelm M and Cortese-Krott MM. Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia. Antioxid Redox Signal. 2017;26:718-742.

Kusters P, Seijkens T, Burger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N and Lutgens E. Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol. 2017;187:2912-2919.

Lachmann V, Makimoto H, Kelm M and Bonner F. Aborted sudden cardiac death: ICD or no ICD. Clin Res Cardiol. 2017;106:760-763.

Lorenz K, Rosner MR, Brand T and Schmitt JP. Raf kinase inhibitor protein: lessons of a better way for beta-adrenergic receptor activation in the heart. J Physiol. 2017;595:4073-4087.

Polzin A, Piayda K, Keul P, Dannenberg L, Mohring A, Graler M, Zeus T, Kelm M and Levkau B. Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. J Mol Cell Cardiol. 2017;110:35-37.

Quast C, Alter C, Ding Z, Borg N and Schrader J. Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure. Circ Heart Fail. 2017;10.

Rohling M, Strom A, Bonhof G, Puttgen S, Bodis K, Mussig K, Szendrodi J, Markgraf D, Lehr S, Roden M, Ziegler D and German Diabetes Study G. Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care. 2017;40:246-252.

Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR and Rosner MR. Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A. 2017;114:13453-13458.

Skyschally A, Amanakis G, Neuhauser M, Kleinbongard P and Heusch G. Impact of electrical defibrillation on infarct size and no-reflow in pigs subjected to myocardial ischemia-reperfusion without and with ischemic conditioning. Am J Physiol Heart Circ Physiol. 2017;313:H871-H878.

Spieker M, Haberkorn S, Gastl M, Behm P, Katsianos S, Horn P, Jacoby C, Schnackenburg B, Reinecke P, Kelm M, Westenfeld R and Bonner F. Abnormal T2 mapping cardiovascular magnetic resonance correlates with adverse clinical outcome in patients with suspected acute myocarditis. J Cardiovasc Magn Reson. 2017;19:38.

Temme S, Friebe D, Schmidt T, Poschmann G, Hesse J, Steckel B, Stuhler K, Kunz M, Dandekar T, Ding Z, Akhyari P, Lichtenberg A and Schrader J. Genetic profiling and surface proteome analysis of human atrial stromal cells and rat ventricular epicardium-derived cells reveals novel insights into their cardiogenic potential. Stem Cell Res. 2017;25:183-190.

Tilg H, Moschen AR and Roden M. NAFLD and diabetes mellitus. Nat Rev Gastroenterol Hepatol. 2017;14:32-42.

Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lammle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechene P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R and El-Armouche A. Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 2017;120:120-132.

Vogtle FN, Burkhart JM, Gonczarowska-Jorge H, Kucukkose C, Taskin AA, Kopczynski D, Ahrends R, Mossmann D, Sickmann A, Zahedi RP and Meisinger C. Landscape of submitochondrial protein distribution. Nat Commun. 2017;8:290.

von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Graler MH and Levkau B. Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood. 2017;130:2786-2798.

Welters A, Kluppel C, Mrugala J, Wormeyer L, Meissner T, Mayatepek E, Heiss C, Eberhard D and Lammert E. NMDAR antagonists for the treatment of diabetes mellitus-Current status and future directions. Diabetes Obes Metab. 2017;19 Suppl 1:95-106.

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Burger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E and Gerdes N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J. 2017;38:3590-3599.

Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Burger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E and Gerdes N. CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost. 2017;117:164-175.

Zhou Z, Menzel F, Benninghoff T, Chadt A, Du C, Holman GD and Al-Hasani H. Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. FEBS Lett. 2017;591:88-96.

Apostolopoulou M, Strassburger K, Herder C, Knebel B, Kotzka J, Szendroedi J, Roden M and group GDS. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes. Diabetologia. 2016;59:2203-7.

Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K and Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016;134:817-32.

Bonner F, Spieker M, Haberkorn S, Jacoby C, Flogel U, Schnackenburg B, Horn P, Reinecke P, Neizel-Wittke M, Kelm M and Westenfeld R. Myocardial T2 Mapping Increases Noninvasive Diagnostic Accuracy for Biopsy-Proven Myocarditis. JACC Cardiovasc Imaging. 2016;9:1467-1469.

Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, Spiranec K, Rock K, Fischer JW, Kammerer U, Stegner D, Baba HA, Hofmann U, Frantz S and Kuhn M. Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. Circ Res. 2016;119:237-48.

Coman C, Solari FA, Hentschel A, Sickmann A, Zahedi RP and Ahrends R. Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology. Mol Cell Proteomics. 2016;15:1453-66.

Cortese-Krott MM, Butler AR, Woollins JD and Feelisch M. Inorganic sulfur-nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling. Dalton Trans. 2016;45:5908-19.

Cortese-Krott MM, Pullmann D and Feelisch M. Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system. Pharmacol Res. 2016;113:490-499.

Dannenberg L, Erschoff V, Bonner F, Gliem M, Jander S, Levkau B, Kelm M, Hohlfeld T, Zeus T and Polzin A. Dipyrone comedication in aspirin treated stroke patients impairs outcome. Vascul Pharmacol. 2016;87:66-69.

Di Pietro N, Giardinelli A, Sirolli V, Riganti C, Di Tomo P, Gazzano E, Di Silvestre S, Panknin C, Cortese-Krott MM, Csonka C, Kelm M, Ferdinandy P, Bonomini M and Pandolfi A. Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients. Mol Cell Biochem. 2016;417:155-67.

Ding Z, Temme S, Quast C, Friebe D, Jacoby C, Zanger K, Bidmon HJ, Grapentin C, Schubert R, Flogel U and Schrader J. Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking. Stem Cells Transl Med. 2016;5:639-50.

Donner L, Falker K, Gremer L, Klinker S, Pagani G, Ljungberg LU, Lothmann K, Rizzi F, Schaller M, Gohlke H, Willbold D, Grenegard M and Elvers M. Platelets contribute to amyloid-beta aggregation in cerebral vessels through integrin alphaIIbbeta3-induced outside-in signaling and clusterin release. Sci Signal. 2016;9:ra52.

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N and Haendeler J. The aryl hydrocarbon receptor promotes aging phenotypes across species. Sci Rep. 2016;6:19618.

Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Muller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR and Fischer JW. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:e41-50.

Hildebrandt HA, Kreienkamp V, Gent S, Kahlert P, Heusch G and Kleinbongard P. Kinetics and Signal Activation Properties of Circulating Factor(s) From Healthy Volunteers Undergoing Remote Ischemic Pre-Conditioning. JACC Basic Transl Sci. 2016;1:3-13.

Keul P, van Borren MM, Ghanem A, Muller FU, Baartscheer A, Verkerk AO, Stumpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schafers M, Peters SL, Chun J and Levkau B. Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. J Am Heart Assoc. 2016;5.

Kiene LS, Homann S, Suvorava T, Rabausch B, Muller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Kohrer K, Savani RC, Grandoch M and Fischer JW. Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. Arterioscler Thromb Vasc Biol. 2016;36:e9-16.

Kleinbongard P, Neuhauser M, Thielmann M, Kottenberg E, Peters J, Jakob H and Heusch G. Confounders of Cardioprotection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting. Cardiology. 2016;133:128-33.

Kotter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll JM, Scheller J, Godecke A, Fischer JW, Schmitt JP and Kruger M. Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction. Circ Res. 2016;119:1017-1029.

Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N and Lutgens E. Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:1748-52.

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Gorg B, Haussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C and Scheller J. Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11alpha Receptor. Cell Rep. 2016;16:1067-1081.

Niermann C, Gorressen S, Klier M, Gowert NS, Billuart P, Kelm M, Merx MW and Elvers M. Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cell Signal. 2016;28:967-78.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ and Hoffmann C. beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature. 2016;531:661-4.

Polzin A, Dannenberg L, Sansone R, Levkau B, Kelm M, Hohlfeld T and Zeus T. Antiplatelet effects of aspirin in chronic kidney disease patients. J Thromb Haemost. 2016;14:375-80.

Polzin A, Dannenberg L, Sophia Popp V, Kelm M and Zeus T. Antiplatelet effects of clopidogrel and aspirin after interventional patent foramen ovale/ atrium septum defect closure. Platelets. 2016;27:317-21.

Rammos C, Hendgen-Cotta UB, Totzeck M, Pohl J, Ludike P, Flogel U, Deenen R, Kohrer K, French BA, Godecke A, Kelm M and Rassaf T. Impact of dietary nitrate on age-related diastolic dysfunction. Eur J Heart Fail. 2016;18:599-610.

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Bohm M, Pullamsetti SS, Ghofrani HA, Godecke A, Jungmann A, Katus HA, Muller OJ, Schermuly RT, Fisslthaler B, Seeger W and Fleming I. miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach. Cardiovasc Res. 2016;111:184-93.

Szendroedi J, Saxena A, Weber KS, Strassburger K, Herder C, Burkart V, Nowotny B, Icks A, Kuss O, Ziegler D, Al-Hasani H, Mussig K, Roden M and Group GDS. Cohort profile: the German Diabetes Study (GDS). Cardiovasc Diabetol. 2016;15:59.

Zurek M, Altschmied J, Kohlgruber S, Ale-Agha N and Haendeler J. Role of Telomerase in the Cardiovascular System. Genes (Basel). 2016;7.

 

Cortese-Krott MM, Kuhnle GG, Dyson A, Fernandez BO, Grman M, DuMond JF, Barrow MP, McLeod G, Nakagawa H, Ondrias K, Nagy P, King SB, Saavedra JE, Keefer LK, Singer M, Kelm M, Butler AR, Feelisch M. Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl. Proc Natl Acad Sci U S A. 2015;112:E4651-60.

Eckers A, Haendeler J. Endothelial cells in health and disease. Antioxid Redox Signal. 2015;22:1209-11.

Erkens R, Kramer CM, Lückstadt W, Panknin C, Krause L, Weidenbach M, Dirzka J, Krenz T, Mergia E, Suvorava T, Kelm M, Cortese-Krott MM. Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function. Free Radic Biol Med. 2015;89:906-17.

Farrokh S, Brillen AL, Haendeler J, Altschmied J, Schaal H. Critical regulators of endothelial cell functions: for a change being alternative. Antioxid Redox Signal. 2015;22:1212-29.

Gorressen S, Stern M, van de Sandt AM, Cortese-Krott MM, Ohlig J, Rassaf T, Gödecke A, Fischer JW, Heusch G, Merx MW, Kelm M. Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction. PLoS One. 2015;10:e0120961.

Grandoch M, Feldmann K, Gothert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Kohrer K, Lehr S, Homey B, Pfeffer K, Fischer JW. Deficiency in lymphotoxin beta receptor protects from atherosclerosis in apoE-deficient mice. Circ Res. 2015;116:e57-68.

Heinen Y, Stegemann E, Sansone R, Benedens K, Wagstaff R, Balzer J, Rassaf T, Lauer T, Kelm M, Heiss C. Local association between endothelial dysfunction and intimal hyperplasia: relevance in peripheral artery disease. J Am Heart Assoc. 2015;4.

Heiss C, Sansone R, Karimi H, Krabbe M, Schuler D, Rodriguez-Mateos A, Kraemer T, Cortese-Krott MM, Kuhnle GG, Spencer JP, Schroeter H, Merx MW, Kelm M, Flaviola Consortium EUtFP. Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr). 2015;37:9794.

Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol. 2015;65:177-95.

Kleinbongard P, Gedik N, Witting P, Freedman B, Klöcker N, Heusch G. Pleiotropic, heart rate-independent cardioprotection by ivabradine. Br J Pharmacol. 2015;172:4380-90.

Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 2015;21:739-46.

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