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Publications

2021

Heusch, G. (2021). Myocardial stunning and hibernation revisited. Nat Rev Cardiol.

Hoffmann, J., Richardson, G., Haendeler, J., Altschmied, J., Andres, V., and Spyridopoulos, I. (2021). Telomerase As a Therapeutic Target in Cardiovascular Disease. Arterioscler Thromb Vasc Biol, ATVBAHA120315695.

 

 

2020

Barbosa, D.M., Fahlbusch, P., Herzfeld de Wiza, D., Jacob, S., Kettel, U., Al-Hasani, H., Kruger, M., Ouwens, D.M., Hartwig, S., Lehr, S., Kotzka, J., and Knebel, B. (2020). Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis. Sci Rep 10, 4888.

Bottermann, K., Granade, M.E., Oenarto, V., Fischer, J.W., and Harris, T.E. (2020). Atglistatin Pretreatment Preserves Remote Myocardium Function Following Myocardial Infarction. J Cardiovasc Pharmacol Ther, 1074248420971113.

Burnap, S.A., Joshi, A., Tsimikas, S., Fernandez-Hernando, C., Kiechl, S., Berry, S.E., Hall, W., Levkau, B., and Mayr, M. (2020). High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation. J Am Coll Cardiol 75, 1495-1497.

Dannenberg, L., Metzen, D., Zako, S., Pohl, M., Mourikis, P., Helten, C., Trojovsky, K., Naguib, D., Konsek, D., Knoop, B., Ayhan, A., Hohlfeld, T., Petzold, T., Levkau, B., Veulemans, V., Zeus, T., Kelm, M., and Polzin, A. (2020a). Enhanced Platelet Reactivity under Aspirin Medication and Major Adverse Cardiac and Cerebrovascular Events in Patients with Coronary Artery Disease. Pharmacology 105, 118-122.

Dannenberg, L., Zikeli, D., Benkhoff, M., Ahlbrecht, S., Kelm, M., Levkau, B., and Polzin, A. (2020b). Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy. Pharmacol Ther 213, 107584.

Del Monte-Nieto, G., Fischer, J.W., Gorski, D.J., Harvey, R.P., and Kovacic, J.C. (2020). Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar. J Am Coll Cardiol 75, 2169-2188.

Helten, C., Mourikis, P., Dannenberg, L., M'Pembele, R., Trojovsky, K., Ayhan, A., Kohlmorgen, C., Grandoch, M., Levkau, B., Veulemans, V., Petzold, T., Hohlfeld, T., Kelm, M., Zeus, T., and Polzin, A. (2020). A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox? Eur J Clin Pharmacol 76, 1245-1251.

Heusch, G. (2020). Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17, 773-789.

Klose, A.M., Klier, M., Gorressen, S., and Elvers, M. (2020). Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction. Int J Mol Sci 21.

Kunzel, S.R., Rausch, J.S.E., Schaffer, C., Hoffmann, M., Kunzel, K., Klapproth, E., Kant, T., Herzog, N., Kupper, J.H., Lorenz, K., Dudek, S., Emig, R., Ravens, U., Rog-Zielinska, E.A., Peyronnet, R., and El-Armouche, A. (2020). Modeling atrial fibrosis in vitro-Generation and characterization of a novel human atrial fibroblast cell line. FEBS Open Bio 10, 1210-1218.

Loescher, C.M., Breitkreuz, M., Li, Y., Nickel, A., Unger, A., Dietl, A., Schmidt, A., Mohamed, B.A., Kotter, S., Schmitt, J.P., Kruger, M., Kruger, M., Toischer, K., Maack, C., Leichert, L.I., Hamdani, N., and Linke, W.A. (2020). Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx). Proc Natl Acad Sci U S A 117, 24545-24556.

Misiou, A., Garmey, J.C., Hensien, J.M., Harmon, D.B., Osinsk, V., McSkimming, C., Marshall, M.A., Fischer, J.W., Grandoch, M., and McNamara, C.A. (2020). Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation. Arterioscler Thromb Vasc Biol, ATVBAHA120315588.

Mourikis, P., Zako, S., Dannenberg, L., Helten, C., Naguib, D., Hohlfeld, T., Petzold, T., Levkau, B., Zeus, T., Kelm, M., and Polzin, A. (2020). Aspirin antiplatelet effects are associated with body weight. Vascul Pharmacol 125-126, 106635.

Ottolini, M., Hong, K., Cope, E.L., Daneva, Z., DeLalio, L.J., Sokolowski, J.D., Marziano, C., Nguyen, N.Y., Altschmied, J., Haendeler, J., Johnstone, S.R., Kalani, M.Y., Park, M.S., Patel, R.P., Liedtke, W., Isakson, B.E., and Sonkusare, S.K. (2020). Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. Circulation 141, 1318-1333.

Petzold, T., Dannenberg, L., Thienel, M., Ahlbrecht, S., Mourikis, P., Helten, C., M'Pembele, R., Achilles, A., Zikeli, D., Zhang, Z., Lusebrink, E., Nicolai, L., Saleh, I., Jung, C., Gerdes, N., Hoffmann, T., Levkau, B., Hohlfeld, T., Zeus, T., Schulz, C., Kelm, M., and Polzin, A. (2020a). Response by Petzold et al to Letter Regarding Article, "Rivaroxaban Reduces Arterial Thrombosis by Inhibition of Fxa-Driven Platelet Activation via Protease Activated Receptor-1". Circ Res 126, e116-e117.

Petzold, T., Thienel, M., Dannenberg, L., Mourikis, P., Helten, C., Ayhan, A., M'Pembele, R., Achilles, A., Trojovky, K., Konsek, D., Zhang, Z., Regenauer, R., Pircher, J., Ehrlich, A., Lusebrink, E., Nicolai, L., Stocker, T.J., Brandl, R., Roschenthaler, F., Strecker, J., Saleh, I., Spannagl, M., Mayr, C.H., Schiller, H.B., Jung, C., Gerdes, N., Hoffmann, T., Levkau, B., Hohlfeld, T., Zeus, T., Schulz, C., Kelm, M., and Polzin, A. (2020b). Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1. Circ Res 126, 486-500.

Rosen, J., Jakobs, P., Ale-Agha, N., Altschmied, J., and Haendeler, J. (2020). Non-canonical functions of Telomerase Reverse Transcriptase - Impact on redox homeostasis. Redox Biol 34, 101543.

Tomasovic, A., Brand, T., Schanbacher, C., Kramer, S., Hummert, M.W., Godoy, P., Schmidt-Heck, W., Nordbeck, P., Ludwig, J., Homann, S., Wiegering, A., Shaykhutdinov, T., Kratz, C., Knuchel, R., Muller-Hermelink, H.K., Rosenwald, A., Frey, N., Eichler, J., Dobrev, D., El-Armouche, A., Hengstler, J.G., Muller, O.J., Hinrichs, K., Cuello, F., Zernecke, A., and Lorenz, K. (2020). Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects. Nat Commun 11, 1733.

 

 

Breitenbach, T., Lorenz, K., and Dandekar, T. (2019). How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency. Int J Mol Sci 20.

Gonnissen, S., Ptok, J., Goy, C., Jander, K., Jakobs, P., Eckermann, O., Kaisers, W., von Ameln, F., Timm, J., Ale-Agha, N., Haendeler, J., Schaal, H., and Altschmied, J. (2019). High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells. Oxid Med Cell Longev 2019, 7976382.

Gorski, D.J., Petz, A., Reichert, C., Twarock, S., Grandoch, M., and Fischer, J.W. (2019). Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance. Sci Rep 9, 1827.

Grandoch, M., Flogel, U., Virtue, S., Maier, J.K., Jelenik, T., Kohlmorgen, C., Feldmann, K., Ostendorf, Y., Castaneda, T.R., Zhou, Z., Yamaguchi, Y., Nascimento, E.B.M., Sunkari, V.G., Goy, C., Kinzig, M., Sorgel, F., Bollyky, P.L., Schrauwen, P., Al-Hasani, H., Roden, M., Keipert, S., Vidal-Puig, A., Jastroch, M., Haendeler, J., and Fischer, J.W. (2019). 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1, 546-559.

Heinen, A., Nederlof, R., Panjwani, P., Spychala, A., Tschaidse, T., Reffelt, H., Boy, J., Raupach, A., Godecke, S., Petzsch, P., Kohrer, K., Grandoch, M., Petz, A., Fischer, J.W., Alter, C., Vasilevska, J., Lang, P., and Godecke, A. (2019). IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells. Mol Ther 27, 46-58.

Henning, C., Branopolski, A., Schuler, D., Dimitroulis, D., Huelsemann, P., Nicolaus, C., Sansone, R., Ludolf Postma, J., Eberhard, D., Le Noble, F., Kelm, M., Lammert, E., and Heiss, C. (2019). Requirement of beta1 integrin for endothelium-dependent vasodilation and collateral formation in hindlimb ischemia. Sci Rep 9, 16931.

Jochmann, S., Elkenani, M., Mohamed, B.A., Buchholz, E., Lbik, D., Binder, L., Lorenz, K., Shah, A.M., Hasenfuss, G., Toischer, K., and Schnelle, M. (2019). Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling. ESC Heart Fail 6, 1015-1026.

Kruger, M. (2019). Remote ischemic preconditioning and beyond-are we getting closer to the secret of cardioprotection? Pflugers Arch 471, 1369-1370.

Maimari, T., Krasel, C., Bunemann, M., and Lorenz, K. (2019). The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on beta-adrenoceptors. Biochem Biophys Res Commun 520, 327-332.

Nagy, N., Gurevich, I., Kuipers, H.F., Ruppert, S.M., Marshall, P.L., Xie, B.J., Sun, W., Malkovskiy, A.V., Rajadas, J., Grandoch, M., Fischer, J.W., Frymoyer, A.R., Kaber, G., and Bollyky, P.L. (2019). 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. J Biol Chem 294, 7864-7877.

Petz, A., Grandoch, M., Gorski, D.J., Abrams, M., Piroth, M., Schneckmann, R., Homann, S., Muller, J., Hartwig, S., Lehr, S., Yamaguchi, Y., Wight, T.N., Gorressen, S., Ding, Z., Kotter, S., Kruger, M., Heinen, A., Kelm, M., Godecke, A., Flogel, U., and Fischer, J.W. (2019). Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury. Circ Res 124, 1433-1447.

Stoian, L., Kruger, M., Schmitt, J., and Kleinbongard, P. (2019). Is there an effect of ischemic conditioning on myocardial contractile function following acute myocardial ischemia/reperfusion injury? Biochim Biophys Acta Mol Basis Dis 1865, 822-830.

Zaharia, O.P., Strassburger, K., Strom, A., Bonhof, G.J., Karusheva, Y., Antoniou, S., Bodis, K., Markgraf, D.F., Burkart, V., Mussig, K., Hwang, J.H., Asplund, O., Groop, L., Ahlqvist, E., Seissler, J., Nawroth, P., Kopf, S., Schmid, S.M., Stumvoll, M., Pfeiffer, A.F.H., Kabisch, S., Tselmin, S., Haring, H.U., Ziegler, D., Kuss, O., Szendroedi, J., Roden, M., and German Diabetes Study, G. (2019). Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 7, 684-694.

 

 

2017

Beck, F., Geiger, J., Gambaryan, S., Solari, F.A., Dell'Aica, M., Loroch, S., Mattheij, N.J., Mindukshev, I., Potz, O., Jurk, K., Burkhart, J.M., Fufezan, C., Heemskerk, J.W., Walter, U., Zahedi, R.P., and Sickmann, A. (2017). Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood 129, e1-e12.

Binsch, C., Jelenik, T., Pfitzer, A., Dille, M., Müller-Lühlhoff, S., Hartwig, S., Karpinski, S., Lehr, S., Kabra, D.G., Chadt, A., Roden, M., Al-Hasani, H., and Castaneda, T.R. (2017). Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress. Mol Metab 6, 1443-1453.

Boege, F., Westenfeld, R., and Jahns, R. (2017). beta1AAb Determined by Peptide ELISA: A Signal in the Noise? J Am Coll Cardiol 70, 807-808.

Borg, N., Alter, C., Gorldt, N., Jacoby, C., Ding, Z., Steckel, B., Quast, C., Bönner, F., Friebe, D., Temme, S., Flögel, U., and Schrader, J. (2017). CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming. Circulation 136, 297-313.

Cortese-Krott, M.M., Koning, A., Kuhnle, G.G.C., Nagy, P., Bianco, C.L., Pasch, A., Wink, D.A., Fukuto, J.M., Jackson, A.A., van Goor, H., Olson, K.R., and Feelisch, M. (2017). The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. Antioxid Redox Signal 27, 684-712.

Erkens, R., Suvorava, T., Kramer, C.M., Diederich, L.D., Kelm, M., and Cortese-Krott, M.M. (2017). Modulation of Local and Systemic Heterocellular Communication by Mechanical Forces: A Role of Endothelial Nitric Oxide Synthase. Antioxid Redox Signal 26, 917-935.

Floss, D.M., Schonberg, M., Franke, M., Horstmeier, F.C., Engelowski, E., Schneider, A., Rosenfeldt, E.M., and Scheller, J. (2017). IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling. Sci Rep 7, 15172.

Gedik, N., Kottenberg, E., Thielmann, M., Frey, U.H., Jakob, H., Peters, J., Heusch, G., and Kleinbongard, P. (2017a). Potential humoral mediators of remote ischemic preconditioning in patients undergoing surgical coronary revascularization. Sci Rep 7, 12660.

Gedik, N., Kruger, M., Thielmann, M., Kottenberg, E., Skyschally, A., Frey, U.H., Cario, E., Peters, J., Jakob, H., Heusch, G., and Kleinbongard, P. (2017b). Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion: remote ischemic preconditioning. Sci Rep 7, 7629.

Gedik, N., Maciel, L., Schulte, C., Skyschally, A., Heusch, G., and Kleinbongard, P. (2017c). Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning. Arch Med Sci 13, 448-458.

Gowert, N.S., Kruger, I., Klier, M., Donner, L., Kipkeew, F., Gliem, M., Bradshaw, N.J., Lutz, D., Kober, S., Langer, H., Jander, S., Jurk, K., Frotscher, M., Korth, C., Bock, H.H., and Elvers, M. (2017). Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal 40, 210-221.

Haberkorn, S.M., Jacoby, C., Ding, Z., Keul, P., Bönner, F., Polzin, A., Levkau, B., Schrader, J., Kelm, M., and Flögel, U. (2017). Cardiovascular Magnetic Resonance Relaxometry Predicts Regional Functional Outcome After Experimental Myocardial Infarction. Circ Cardiovasc Imaging 10.

Hendgen-Cotta, U.B., Esfeld, S., Coman, C., Ahrends, R., Klein-Hitpass, L., Flögel, U., Rassaf, T., and Totzeck, M. (2017). A novel physiological role for cardiac myoglobin in lipid metabolism. Sci Rep 7, 43219.

Hernandez, E.A., Kahl, S., Seelig, A., Begovatz, P., Irmler, M., Kupriyanova, Y., Nowotny, B., Nowotny, P., Herder, C., Barosa, C., Carvalho, F., Rozman, J., Neschen, S., Jones, J.G., Beckers, J., de Angelis, M.H., and Roden, M. (2017). Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest 127, 695-708.

Hesse, J., Leberling, S., Boden, E., Friebe, D., Schmidt, T., Ding, Z., Dieterich, P., Deussen, A., Roderigo, C., Rose, C.R., Floss, D.M., Scheller, J., and Schrader, J. (2017). CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction. FASEB J 31, 3040-3053.

Heusch, G. (2017). Critical Issues for the Translation of Cardioprotection. Circ Res 120, 1477-1486.

Hilfiker-Kleiner, D., Haghikia, A., Berliner, D., Vogel-Claussen, J., Schwab, J., Franke, A., Schwarzkopf, M., Ehlermann, P., Pfister, R., Michels, G., Westenfeld, R., Stangl, V., Kindermann, I., Kuhl, U., Angermann, C.E., Schlitt, A., Fischer, D., Podewski, E., Bohm, M., Sliwa, K., and Bauersachs, J. (2017). Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J 38, 2671-2679.

Hummel, T.M., Ackfeld, T., Schonberg, M., Ciupka, G., Schulz, F., Oberdoerster, A., Grötzinger, J., Scheller, J., and Floss, D.M. (2017). Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol 37.

Jelenik, T., Kaul, K., Sequaris, G., Flogel, U., Phielix, E., Kotzka, J., Knebel, B., Fahlbusch, P., Horbelt, T., Lehr, S., Reinbeck, A.L., Muller-Wieland, D., Esposito, I., Shulman, G.I., Szendroedi, J., and Roden, M. (2017). Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes 66, 2241-2253.

Jungen, C., Scherschel, K., Eickholt, C., Kuklik, P., Klatt, N., Bork, N., Salzbrunn, T., Alken, F., Angendohr, S., Klene, C., Mester, J., Klöcker, N., Veldkamp, M.W., Schumacher, U., Willems, S., Nikolaev, V.O., and Meyer, C. (2017). Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun 8, 14155.

Keller, A.S., Diederich, L., Panknin, C., DeLalio, L.J., Drake, J.C., Sherman, R., Jackson, E.K., Yan, Z., Kelm, M., Cortese-Krott, M.M., and Isakson, B.E. (2017). Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol 313, C593-C603.

Klier, M., Gowert, N.S., Jäckel, S., Reinhardt, C., and Elvers, M. (2017). Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal 38, 171-181.

Kuhn, V., Diederich, L., Keller, T.C.S.t., Kramer, C.M., Luckstadt, W., Panknin, C., Suvorava, T., Isakson, B.E., Kelm, M., and Cortese-Krott, M.M. (2017). Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia. Antioxid Redox Signal 26, 718-742.

Kusters, P., Seijkens, T., Burger, C., Legein, B., Winkels, H., Gijbels, M., Barthels, C., Bennett, R., Beckers, L., Atzler, D., Biessen, E., Brocker, T., Weber, C., Gerdes, N., and Lutgens, E. (2017). Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol 187, 2912-2919.

Lorenz, K., Rosner, M.R., Brand, T., and Schmitt, J.P. (2017). Raf kinase inhibitor protein: lessons of a better way for beta-adrenergic receptor activation in the heart. J Physiol 595, 4073-4087.

Polzin, A., Piayda, K., Keul, P., Dannenberg, L., Mohring, A., Graler, M., Zeus, T., Kelm, M., and Levkau, B. (2017). Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. J Mol Cell Cardiol 110, 35-37.

Quast, C., Alter, C., Ding, Z., Borg, N., and Schrader, J. (2017). Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure. Circ Heart Fail 10.

Rohling, M., Strom, A., Bonhof, G., Puttgen, S., Bodis, K., Mussig, K., Szendrodi, J., Markgraf, D., Lehr, S., Roden, M., Ziegler, D., and German Diabetes Study, G. (2017). Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care 40, 246-252.

Skinner, J.J., Wang, S., Lee, J., Ong, C., Sommese, R., Sivaramakrishnan, S., Koelmel, W., Hirschbeck, M., Schindelin, H., Kisker, C., Lorenz, K., Sosnick, T.R., and Rosner, M.R. (2017). Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A 114, 13453-13458.

Skyschally, A., Amanakis, G., Neuhauser, M., Kleinbongard, P., and Heusch, G. (2017). Impact of electrical defibrillation on infarct size and no-reflow in pigs subjected to myocardial ischemia-reperfusion without and with ischemic conditioning. Am J Physiol Heart Circ Physiol 313, H871-H878.

Temme, S., Friebe, D., Schmidt, T., Poschmann, G., Hesse, J., Steckel, B., Stuhler, K., Kunz, M., Dandekar, T., Ding, Z., Akhyari, P., Lichtenberg, A., and Schrader, J. (2017). Genetic profiling and surface proteome analysis of human atrial stromal cells and rat ventricular epicardium-derived cells reveals novel insights into their cardiogenic potential. Stem Cell Res 25, 183-190.

Tilg, H., Moschen, A.R., and Roden, M. (2017). NAFLD and diabetes mellitus. Nat Rev Gastroenterol Hepatol 14, 32-42.

Vettel, C., Lindner, M., Dewenter, M., Lorenz, K., Schanbacher, C., Riedel, M., Lammle, S., Meinecke, S., Mason, F.E., Sossalla, S., Geerts, A., Hoffmann, M., Wunder, F., Brunner, F.J., Wieland, T., Mehel, H., Karam, S., Lechene, P., Leroy, J., Vandecasteele, G., Wagner, M., Fischmeister, R., and El-Armouche, A. (2017). Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res 120, 120-132.

Vogtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kucukkose, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat Commun 8, 290.

von Wnuck Lipinski, K., Weske, S., Keul, P., Peters, S., Baba, H.A., Heusch, G., Graler, M.H., and Levkau, B. (2017). Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood 130, 2786-2798.

Welters, A., Klüppel, C., Mrugala, J., Wörmeyer, L., Meissner, T., Mayatepek, E., Heiss, C., Eberhard, D., and Lammert, E. (2017). NMDAR antagonists for the treatment of diabetes mellitus-Current status and future directions. Diabetes Obes Metab 19 Suppl 1, 95-106.

Winkels, H., Meiler, S., Lievens, D., Engel, D., Spitz, C., Burger, C., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Hartwig, H., Holdt, L.M., Hristov, M., Megens, R.T.A., Schmitt, M.M., Biessen, E.A., Borst, J., Faussner, A., Weber, C., Lutgens, E., and Gerdes, N. (2017a). CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J 38, 3590-3599.

Winkels, H., Meiler, S., Smeets, E., Lievens, D., Engel, D., Spitz, C., Burger, C., Rinne, P., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Van den Bossche, J., Holdt, L.M., Megens, R.T., Schmitt, M., de Winther, M., Biessen, E.A., Borst, J., Faussner, A., Weber, C., Lutgens, E., and Gerdes, N. (2017b). CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost 117, 164-175.

Zhou, Z., Menzel, F., Benninghoff, T., Chadt, A., Du, C., Holman, G.D., and Al-Hasani, H. (2017). Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. FEBS Lett 591, 88-96.

 

2016

Barallobre-Barreiro, J., Gupta, S.K., Zoccarato, A., Kitazume-Taneike, R., Fava, M., Yin, X., Werner, T., Hirt, M.N., Zampetaki, A., Viviano, A., Chong, M., Bern, M., Kourliouros, A., Domenech, N., Willeit, P., Shah, A.M., Jahangiri, M., Schaefer, L., Fischer, J.W., Iozzo, R.V., Viner, R., Thum, T., Heineke, J., Kichler, A., Otsu, K., and Mayr, M. (2016). Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134, 817-832.

Bönner, F., Spieker, M., Haberkorn, S., Jacoby, C., Flögel, U., Schnackenburg, B., Horn, P., Reinecke, P., Neizel-Wittke, M., Kelm, M., and Westenfeld, R. (2016). Myocardial T2 Mapping Increases Noninvasive Diagnostic Accuracy for Biopsy-Proven Myocarditis. JACC Cardiovasc Imaging 9, 1467-1469.

Chen, W., Spitzl, A., Mathes, D., Nikolaev, V.O., Werner, F., Weirather, J., Spiranec, K., Rock, K., Fischer, J.W., Kammerer, U., Stegner, D., Baba, H.A., Hofmann, U., Frantz, S., and Kuhn, M. (2016). Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. Circ Res 119, 237-248.

Coman, C., Solari, F.A., Hentschel, A., Sickmann, A., Zahedi, R.P., and Ahrends, R. (2016). Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology. Mol Cell Proteomics 15, 1453-1466.

Cortese-Krott, M.M., Butler, A.R., Woollins, J.D., and Feelisch, M. (2016a). Inorganic sulfur-nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling. Dalton Trans 45, 5908-5919.

Cortese-Krott, M.M., Pullmann, D., and Feelisch, M. (2016b). Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system. Pharmacol Res 113, 490-499.

Di Pietro, N., Giardinelli, A., Sirolli, V., Riganti, C., Di Tomo, P., Gazzano, E., Di Silvestre, S., Panknin, C., Cortese-Krott, M.M., Csonka, C., Kelm, M., Ferdinandy, P., Bonomini, M., and Pandolfi, A. (2016). Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients. Mol Cell Biochem 417, 155-167.

Ding, Z., Temme, S., Quast, C., Friebe, D., Jacoby, C., Zanger, K., Bidmon, H.J., Grapentin, C., Schubert, R., Flögel, U., and Schrader, J. (2016). Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking. Stem Cells Transl Med 5, 639-650.

Eckers, A., Jakob, S., Heiss, C., Haarmann-Stemmann, T., Goy, C., Brinkmann, V., Cortese-Krott, M.M., Sansone, R., Esser, C., Ale-Agha, N., Altschmied, J., Ventura, N., and Haendeler, J. (2016). The aryl hydrocarbon receptor promotes aging phenotypes across species. Sci Rep 6, 19618.

Grandoch, M., Kohlmorgen, C., Melchior-Becker, A., Feldmann, K., Homann, S., Muller, J., Kiene, L.S., Zeng-Brouwers, J., Schmitz, F., Nagy, N., Polzin, A., Gowert, N.S., Elvers, M., Skroblin, P., Yin, X., Mayr, M., Schaefer, L., Tannock, L.R., and Fischer, J.W. (2016). Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol 36, e41-50.

Keul, P., van Borren, M.M., Ghanem, A., Muller, F.U., Baartscheer, A., Verkerk, A.O., Stumpel, F., Schulte, J.S., Hamdani, N., Linke, W.A., van Loenen, P., Matus, M., Schmitz, W., Stypmann, J., Tiemann, K., Ravesloot, J.H., Alewijnse, A.E., Hermann, S., Spijkers, L.J., Hiller, K.H., Herr, D., Heusch, G., Schafers, M., Peters, S.L., Chun, J., and Levkau, B. (2016). Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. J Am Heart Assoc 5.

Kiene, L.S., Homann, S., Suvorava, T., Rabausch, B., Muller, J., Kojda, G., Kretschmer, I., Twarock, S., Dai, G., Deenen, R., Hartwig, S., Lehr, S., Kohrer, K., Savani, R.C., Grandoch, M., and Fischer, J.W. (2016). Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. Arterioscler Thromb Vasc Biol 36, e9-16.

Kötter, S., Kazmierowska, M., Andresen, C., Bottermann, K., Grandoch, M., Gorressen, S., Heinen, A., Moll, J.M., Scheller, J., Gödecke, A., Fischer, J.W., Schmitt, J.P., and Krüger, M. (2016). Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction. Circ Res 119, 1017-1029.

Meiler, S., Smeets, E., Winkels, H., Shami, A., Pascutti, M.F., Nolte, M.A., Beckers, L., Weber, C., Gerdes, N., and Lutgens, E. (2016). Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report. Arterioscler Thromb Vasc Biol 36, 1748-1752.

Monhasery, N., Moll, J., Cuman, C., Franke, M., Lamertz, L., Nitz, R., Gorg, B., Haussinger, D., Lokau, J., Floss, D.M., Piekorz, R., Dimitriadis, E., Garbers, C., and Scheller, J. (2016). Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11alpha Receptor. Cell Rep 16, 1067-1081.

Niermann, C., Gorressen, S., Klier, M., Gowert, N.S., Billuart, P., Kelm, M., Merx, M.W., and Elvers, M. (2016). Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cell Signal 28, 967-978.

Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., Tobin, A.B., Lohse, M.J., and Hoffmann, C. (2016). beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature 531, 661-664.

Rammos, C., Hendgen-Cotta, U.B., Totzeck, M., Pohl, J., Ludike, P., Flögel, U., Deenen, R., Kohrer, K., French, B.A., Gödecke, A., Kelm, M., and Rassaf, T. (2016). Impact of dietary nitrate on age-related diastolic dysfunction. Eur J Heart Fail 18, 599-610.

Shi, L., Kojonazarov, B., Elgheznawy, A., Popp, R., Dahal, B.K., Bohm, M., Pullamsetti, S.S., Ghofrani, H.A., Gödecke, A., Jungmann, A., Katus, H.A., Muller, O.J., Schermuly, R.T., Fisslthaler, B., Seeger, W., and Fleming, I. (2016). miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach. Cardiovasc Res 111, 184-193.

Szendroedi, J., Saxena, A., Weber, K.S., Strassburger, K., Herder, C., Burkart, V., Nowotny, B., Icks, A., Kuss, O., Ziegler, D., Al-Hasani, H., Mussig, K., Roden, M., and Group, G.D.S. (2016). Cohort profile: the German Diabetes Study (GDS). Cardiovasc Diabetol 15, 59.

Zurek, M., Altschmied, J., Kohlgrüber, S., Ale-Agha, N., and Haendeler, J. (2016). Role of Telomerase in the Cardiovascular System. Genes (Basel) 7, 29.

 

2018

Ale-Agha, N., Goy, C., Jakobs, P., Spyridopoulos, I., Gonnissen, S., Dyballa-Rukes, N., Aufenvenne, K., von Ameln, F., Zurek, M., Spannbrucker, T., Eckermann, O., Jakob, S., Gorressen, S., Abrams, M., Grandoch, M., Fischer, J.W., Kohrer, K., Deenen, R., Unfried, K., Altschmied, J., and Haendeler, J. (2018). CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. PLoS Biol 16, e2004408.

Bianco, C.L., Savitsky, A., Feelisch, M., and Cortese-Krott, M.M. (2018). Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells. Biochem Pharmacol 149, 163-173.

Cortese-Krott, M.M., Mergia, E., Kramer, C.M., Luckstadt, W., Yang, J., Wolff, G., Panknin, C., Bracht, T., Sitek, B., Pernow, J., Stasch, J.P., Feelisch, M., Koesling, D., and Kelm, M. (2018). Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease. Redox Biol 14, 328-337.

Diederich, L., Suvorava, T., Sansone, R., Keller, T.C.S.t., Barbarino, F., Sutton, T.R., Kramer, C.M., Luckstadt, W., Isakson, B.E., Gohlke, H., Feelisch, M., Kelm, M., and Cortese-Krott, M.M. (2018). On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability. Front Physiol 9, 332.

Engelowski, E., Modares, N.F., Gorressen, S., Bouvain, P., Semmler, D., Alter, C., Ding, Z., Flogel, U., Schrader, J., Xu, H., Lang, P.A., Fischer, J., Floss, D.M., and Scheller, J. (2018a). IL-23R Signaling Plays No Role in Myocardial Infarction. Sci Rep 8, 17078.

Engelowski, E., Schneider, A., Franke, M., Xu, H., Clemen, R., Lang, A., Baran, P., Binsch, C., Knebel, B., Al-Hasani, H., Moll, J.M., Floss, D.M., Lang, P.A., and Scheller, J. (2018b). Synthetic cytokine receptors transmit biological signals using artificial ligands. Nat Commun 9, 2034.

Erkens, R., Suvorava, T., Sutton, T.R., Fernandez, B.O., Mikus-Lelinska, M., Barbarino, F., Flogel, U., Kelm, M., Feelisch, M., and Cortese-Krott, M.M. (2018). Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection. Oxid Med Cell Longev.

Fehrentz, T., Huber, F.M.E., Hartrampf, N., Bruegmann, T., Frank, J.A., Fine, N.H.F., Malan, D., Danzl, J.G., Tikhonov, D.B., Sumser, M., Sasse, P., Hodson, D.J., Zhorov, B.S., Klocker, N., and Trauner, D. (2018). Optical control of L-type Ca(2+) channels using a diltiazem photoswitch. Nat Chem Biol 14, 764-767.

Fischer, J.W. (2018). Role of hyaluronan in atherosclerosis: Current knowledge and open questions. Matrix Biol.

Grandoch, M., Bollyky, P.L., and Fischer, J.W. (2018). Hyaluronan: A Master Switch Between Vascular Homeostasis and Inflammation. Circ Res 122, 1341-1343.

Heinen, A., Behmenburg, F., Aytulun, A., Dierkes, M., Zerbin, L., Kaisers, W., Schaefer, M., Meyer-Treschan, T., Feit, S., Bauer, I., Hollmann, M.W., and Huhn, R. (2018a). The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent. J Transl Med 16, 112.

Heinen, A., Raupach, A., Behmenburg, F., Holscher, N., Flogel, U., Kelm, M., Kaisers, W., Nederlof, R., Huhn, R., and Godecke, A. (2018b). Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method. Ultrasound Med Biol 44, 1544-1555.

Heiss, C., Spyridopoulos, I., and Haendeler, J. (2018). Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol 109, 108-118.

Hendgen-Cotta, U.B., Esfeld, S., Jastrow, H., Totzeck, M., Altschmied, J., Goy, C., Haendeler, J., Winterhager, E., and Rassaf, T. (2018). Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations. Mitochondrion 38, 1-5.

Homann, S., Grandoch, M., Kiene, L.S., Podsvyadek, Y., Feldmann, K., Rabausch, B., Nagy, N., Lehr, S., Kretschmer, I., Oberhuber, A., Bollyky, P., and Fischer, J.W. (2018). Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biol 66, 67-80.

Hopf, A.E., Andresen, C., Kotter, S., Isic, M., Ulrich, K., Sahin, S., Bongardt, S., Roell, W., Drove, F., Scheerer, N., Vandekerckhove, L., De Keulenaer, G.W., Hamdani, N., Linke, W.A., and Kruger, M. (2018). Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1. Circ Res.

Jelenik, T., Dille, M., Muller-Luhlhoff, S., Kabra, D.G., Zhou, Z., Binsch, C., Hartwig, S., Lehr, S., Chadt, A., Peters, E.M.J., Kruse, J., Roden, M., Al-Hasani, H., and Castaneda, T.R. (2018a). FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab.

Jelenik, T., Flogel, U., Alvarez-Hernandez, E., Scheiber, D., Zweck, E., Ding, Z., Rothe, M., Mastrototaro, L., Kohlhaas, V., Kotzka, J., Knebel, B., Muller-Wieland, D., Moellendorf, S., Godecke, A., Kelm, M., Westenfeld, R., Roden, M., and Szendroedi, J. (2018b). Insulin Resistance and Vulnerability to Cardiac Ischemia. Diabetes.

Keul, P., Polzin, A., Kaiser, K., Graler, M., Dannenberg, L., Daum, G., Heusch, G., and Levkau, B. (2018). Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB J, fj201801245R.

Klatt, C., Kruger, I., Zey, S., Krott, K.J., Spelleken, M., Gowert, N.S., Oberhuber, A., Pfaff, L., Luckstadt, W., Jurk, K., Schaller, M., Al-Hasani, H., Schrader, J., Massberg, S., Stark, K., Schelzig, H., Kelm, M., and Elvers, M. (2018). Platelet-RBC interaction mediated by FasL-FasR induces procoagulant activity important for thrombosis. J Clin Invest 128, 3906-3925.

Kleinbongard, P., Amanakis, G., Skyschally, A., and Heusch, G. (2018a). Reflection of Cardioprotection by Remote Ischemic Perconditioning in Attenuated ST-Segment Elevation During Ongoing Coronary Occlusion in Pigs: Evidence for Cardioprotection From Ischemic Injury. Circ Res 122, 1102-1108.

Kleinbongard, P., Peters, J., Jakob, H., Heusch, G., and Thielmann, M. (2018b). Persistent Survival Benefit From Remote Ischemic Pre-Conditioning in Patients Undergoing Coronary Artery Bypass Surgery. J Am Coll Cardiol 71, 252-254.

Klier, M., Gorressen, S., Urbahn, M.A., Barbosa, D., Ouwens, M., Fischer, J.W., and Elvers, M. (2018). Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-alpha Regulation and Myocardial Healing. Front Physiol 9, 1698.

Kronenbitter, A., Funk, F., Hackert, K., Gorressen, S., Glaser, D., Boknik, P., Poschmann, G., Stuhler, K., Isic, M., Kruger, M., and Schmitt, J.P. (2018). Impaired Ca(2+) cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction. J Mol Cell Cardiol 119, 28-39.

Kusters, P.J.H., Seijkens, T.T.P., Beckers, L., Lievens, D., Winkels, H., de Waard, V., Duijvestijn, A., Lindquist Liljeqvist, M., Roy, J., Daugherty, A., Newby, A., Gerdes, N., and Lutgens, E. (2018). CD40L Deficiency Protects Against Aneurysm Formation. Arterioscler Thromb Vasc Biol 38, 1076-1085.

Mafakheri, S., Chadt, A., and Al-Hasani, H. (2018). Regulation of RabGAPs involved in insulin action. Biochem Soc Trans 46, 683-690.

Michaud, S.A., Sinclair, N.J., Pětrošová, H., Palmer, A.L., Pistawka, A.J., Zhang, S., Hardie, D.B., Mohammed, Y., Eshghi, A., Richard, V.R., Sickmann, A., and Borchers, C.H. (2018). Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Communications Biology 1, 78.

Nguyen, T.D., Schwarzer, M., Schrepper, A., Amorim, P.A., Blum, D., Hain, C., Faerber, G., Haendeler, J., Altschmied, J., and Doenst, T. (2018). Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts. J Am Heart Assoc 7.

Olson, K.R., Gao, Y., Arif, F., Arora, K., Patel, S., DeLeon, E.R., Sutton, T.R., Feelisch, M., Cortese-Krott, M.M., and Straub, K.D. (2018). Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase. Redox Biol 15, 74-85.

Sansone, R., Baaken, M., Horn, P., Schuler, D., Westenfeld, R., Amabile, N., Kelm, M., and Heiss, C. (2018). Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease. Data Brief 19, 495-500.

Scheiber, D., Zweck, E., Jelenik, T., Horn, P., Albermann, S., Masyuk, M., Boeken, U., Saeed, D., Kelm, M., Roden, M., Szendroedi, J., and Westenfeld, R. (2018). Reduced Myocardial Mitochondrial ROS Production in Mechanically Unloaded Hearts. J Cardiovasc Transl Res.

Seijkens, T.T.P., van Tiel, C.M., Kusters, P.J.H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S., Lameijer, M., Gijbels, M.J., Beckers, L., den Toom, M., Slutter, B., Kuiper, J., Duchene, J., Aslani, M., Megens, R.T.A., van 't Veer, C., Kooij, G., Schrijver, R., Hoeksema, M.A., Boon, L., Fay, F., Tang, J., Baxter, S., Jongejan, A., Moerland, P.D., Vriend, G., Bleijlevens, B., Fisher, E.A., Duivenvoorden, R., Gerdes, N., de Winther, M.P.J., Nicolaes, G.A., Mulder, W.J.M., Weber, C., and Lutgens, E. (2018). Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol 71, 527-542.

Skyschally, A., Kleinbongard, P., Lieder, H., Gedik, N., Stoian, L., Amanakis, G., Elbers, E., and Heusch, G. (2018). Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice. Am J Physiol Heart Circ Physiol 315, H159-H172.

Spieker, M., Katsianos, E., Gastl, M., Behm, P., Horn, P., Jacoby, C., Schnackenburg, B., Reinecke, P., Kelm, M., Westenfeld, R., and Bonner, F. (2018). T2 mapping cardiovascular magnetic resonance identifies the presence of myocardial inflammation in patients with dilated cardiomyopathy as compared to endomyocardial biopsy. Eur Heart J Cardiovasc Imaging 19, 574-582.

Sutton, T.R., Minnion, M., Barbarino, F., Koster, G., Fernandez, B.O., Cumpstey, A.F., Wischmann, P., Madhani, M., Frenneaux, M.P., Postle, A.D., Cortese-Krott, M.M., and Feelisch, M. (2018). A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Redox Biol 16, 359-380.

Tura, A., Chemello, G., Szendroedi, J., Gobl, C., Faerch, K., Vrbikova, J., Pacini, G., Ferrannini, E., and Roden, M. (2018). Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index. Diabetologia 61, 1135-1141.

Urbahn, M.A., Kaup, S.C., Reusswig, F., Kruger, I., Spelleken, M., Jurk, K., Klier, M., Lang, P.A., and Elvers, M. (2018). Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep 8, 10006.

Weske, S., Vaidya, M., Reese, A., von Wnuck Lipinski, K., Keul, P., Bayer, J.K., Fischer, J.W., Flogel, U., Nelsen, J., Epple, M., Scatena, M., Schwedhelm, E., Dorr, M., Volzke, H., Moritz, E., Hannemann, A., Rauch, B.H., Graler, M.H., Heusch, G., and Levkau, B. (2018). Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat Med 24, 667-678.

 

2015

Cortese-Krott, M.M., Kuhnle, G.G., Dyson, A., Fernandez, B.O., Grman, M., DuMond, J.F., Barrow, M.P., McLeod, G., Nakagawa, H., Ondrias, K., Nagy, P., King, S.B., Saavedra, J.E., Keefer, L.K., Singer, M., Kelm, M., Butler, A.R., and Feelisch, M. (2015). Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl. Proc Natl Acad Sci U S A 112, E4651-4660.

Eckers, A., and Haendeler, J. (2015). Endothelial cells in health and disease. Antioxid Redox Signal 22, 1209-1211.

Erkens, R., Kramer, C.M., Lückstadt, W., Panknin, C., Krause, L., Weidenbach, M., Dirzka, J., Krenz, T., Mergia, E., Suvorava, T., Kelm, M., and Cortese-Krott, M.M. (2015). Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function. Free Radic Biol Med 89, 906-917.

Gorressen, S., Stern, M., van de Sandt, A.M., Cortese-Krott, M.M., Ohlig, J., Rassaf, T., Gödecke, A., Fischer, J.W., Heusch, G., Merx, M.W., and Kelm, M. (2015). Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction. PLoS One 10, e0120961.

Grandoch, M., Feldmann, K., Gothert, J.R., Dick, L.S., Homann, S., Klatt, C., Bayer, J.K., Waldheim, J.N., Rabausch, B., Nagy, N., Oberhuber, A., Deenen, R., Kohrer, K., Lehr, S., Homey, B., Pfeffer, K., and Fischer, J.W. (2015). Deficiency in lymphotoxin beta receptor protects from atherosclerosis in apoE-deficient mice. Circ Res 116, e57-68.

Heiss, C., Sansone, R., Karimi, H., Krabbe, M., Schuler, D., Rodriguez-Mateos, A., Kraemer, T., Cortese-Krott, M.M., Kuhnle, G.G., Spencer, J.P., Schroeter, H., Merx, M.W., Kelm, M., and Flaviola Consortium, E.U.t.F.P. (2015). Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr) 37, 9794.

Heusch, G., Botker, H.E., Przyklenk, K., Redington, A., and Yellon, D. (2015). Remote ischemic conditioning. J Am Coll Cardiol 65, 177-195.

Kleinbongard, P., Gedik, N., Witting, P., Freedman, B., Klöcker, N., and Heusch, G. (2015). Pleiotropic, heart rate-independent cardioprotection by ivabradine. Br J Pharmacol 172, 4380-4390.

Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W.T., Schlensak, M., and Roden, M. (2015). Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21, 739-746.

Marquard, J., Otter, S., Welters, A., Stirban, A., Fischer, A., Eglinger, J., Herebian, D., Kletke, O., Klemen, M.S., Stozer, A., Wnendt, S., Piemonti, L., Kohler, M., Ferrer, J., Thorens, B., Schliess, F., Rupnik, M.S., Heise, T., Berggren, P.O., Klocker, N., Meissner, T., Mayatepek, E., Eberhard, D., Kragl, M., and Lammert, E. (2015). Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med 21, 363-372.

Navarese, E.P., Kolodziejczak, M., Schulze, V., Gurbel, P.A., Tantry, U., Lin, Y., Brockmeyer, M., Kandzari, D.E., Kubica, J.M., D'Agostino, R.B., Sr., Kubica, J., Volpe, M., Agewall, S., Kereiakes, D.J., and Kelm, M. (2015). Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. Ann Intern Med 163, 40-51.

Nussbaum, C., Bannenberg, S., Keul, P., Graler, M.H., Goncalves-de-Albuquerque, C.F., Korhonen, H., von Wnuck Lipinski, K., Heusch, G., de Castro Faria Neto, H.C., Rohwedder, I., Gothert, J.R., Prasad, V.P., Haufe, G., Lange-Sperandio, B., Offermanns, S., Sperandio, M., and Levkau, B. (2015). Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun 6, 6416.

Schmid, E., Neef, S., Berlin, C., Tomasovic, A., Kahlert, K., Nordbeck, P., Deiss, K., Denzinger, S., Herrmann, S., Wettwer, E., Weidendorfer, M., Becker, D., Schafer, F., Wagner, N., Ergun, S., Schmitt, J.P., Katus, H.A., Weidemann, F., Ravens, U., Maack, C., Hein, L., Ertl, G., Muller, O.J., Maier, L.S., Lohse, M.J., and Lorenz, K. (2015). Cardiac RKIP induces a beneficial beta-adrenoceptor-dependent positive inotropy. Nat Med 21, 1298-1306.

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