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Project B12 (Roden/Kelm)

Insulin resistance, diabetes and metabolic liver diseases in acute myocardial infarction

This project aims at characterizing the role of insulin resistance, typical for type 2 diabetes, in cardiac and systemic metabolism and organ crosstalk in patients with STEMI. This collaboration of cardiologists and diabetologists will enable concerted state-of-art analysis of heart function and pathogenic mechanisms (energy metabolism, inflammation) including magnetic resonance. This project has a key role within this CRC for detecting subphenotypes allowing for risk stratification of these patients with - at present - worse outcome and by serving as platform for experimental projects to identify metabolic targets for diagnostic and therapeutic interventions.

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